卟吩-f二甲酯合成及其反应机理研究  

Reaction Route and Mechanism of Synthesis of Dimethyl Chlorin-f

作　　者：李付国[1] 赵丽丽[1] 李韵伟[1] 王进军[1] 

机构地区：[1]烟台大学药学院,山东烟台264005

出　　处：《烟台大学学报（自然科学与工程版）》2008年第3期185-190,共6页Journal of Yantai University(Natural Science and Engineering Edition)

基　　金：山东省教育厅资助项目(200391006008)

摘　　要：以叶绿素-a为起始原料,经酸性剔除中心金属镁离子得到脱镁叶绿酸-a甲酯.再经过空气氧化和重排反应将其转变为红紫素18-甲酯,在碱性条件下实施开环和脱羧反应,分别得到卟吩p6三甲酯、卟吩-f二甲酯.选择焦脱镁叶绿酸-a甲酯为起始原料,乙醇钠存在条件下进行空气氧化反应,则分别得到15-甲酰基卟吩-f二甲酯和卟吩-f二甲酯.表征了反应产物的化学结构,讨论和提出了可能的反应机理.Chlorophyll-α is used as starting material and converted to methyl pheophorbide-α by removing mag- nesium under acid condition. The purpurin-18 methyl ester is obtained by air oxidation and rearrangement and chlorin p6 trimethyl ester and chlorin-f dimethyl ester are generated by ring-opening and decarboxylation. 15- formyl chlorin-f and chlorin-f are also obtained from pyropheophorbide-α by air-oxidation in the presence of NaOEt. The structures of all these new compounds are characterized by elemental analysis, UV, IR and ^1H NMR spectra. The possible reaction mechanism is discussed.

关 键 词：焦脱镁叶绿酸-α甲酯 卟吩-f二甲酯 叶绿素衍生物 光动力疗癌法(PDT) 

分 类 号：O62[理学—有机化学]