国产吉西他滨联合卡铂治疗复发性乳腺癌的临床研究  

Clinical Research on Recurrent Breast Cancer Treatment with Gemcitabine Combined with Carboplatin

作　　者：余更生[1] 吕华珠[1] 李春鸣[1] 

机构地区：[1]广东江门市中心医院肿瘤科,江门529070

出　　处：《白求恩军医学院学报》2008年第4期200-201,共2页Journal of Bethune Military Medical College

摘　　要：目的观察国产吉西他滨联合卡铂治疗复发性乳腺癌的疗效和毒性。方法吉西他滨1200mg／m2，用生理盐水稀释后静脉滴注30min，第1天，第8天；卡铂350mg/m^2，加入5％葡萄糖500ml中静脉滴注2h，第2天；21d为1个周期。结果40例人选患者中，完全缓解1例（2．5％），部分缓解16例（40．0％），稳定15例（37．5％），进展8例（20．0％），总有效率为42．5％；中位疾病进展时间4．8个月（1～15个月）；1年生存率47．5％。最常见的毒副反应为恶心、呕吐．骨髓抑制和皮疹。结论吉西他滨联合卡铂治疗复发性乳腺癌，有效率较高，毒副反应可耐受，值得在临床推广使用。Objective To investigate the effect and toxicity of gemcitabine combined with carboplatin treatment on recurrent breast cancer. Methods On the first day and eighth day, gemcitabine（ 1200 mg/m2 ） was diluted with physiologic saline and then used through intravenous drip. on the second day, 350 mg/m2 carboplatin dissolved in 5% glucose solution（500 ml） was used. One cycle lasted for 21 days. Results Among 40 patients, there were 1 complete response（2.5% ）, 16 partial responses（40.0% ）, 15 stable（37.5.0% ） ,8 progressive（20.0% ） .The total effective rate was 42.5 %. Median time to progression was 4.8 months and 1 - year survival rate was 47.5 %. The common toxicities included hanna, vomiting, bone marrow depression and rash. Conclusion The gemcitabine combined with carboplatin for the treatmend of recurrent breast cancer is effective and has endurable toxicities and deserves promoting.

关 键 词：乳腺癌 化学疗法 吉西他滨 卡铂 

分 类 号：R737.9[医药卫生—肿瘤]