幽门螺杆菌感染对胃粘膜上皮过度增生的影响  

STUDIES ON HELICOBACTERIUM PYLORI CAUSING HYPERPROLIFERATION OF GASTRIC EPITHELIUM

作　　者：司志业[1] 岳彩玲[1] 

机构地区：[1]济宁医学院附属医院

出　　处：《济宁医学院学报》1997年第2期19-20,共2页Journal of Jining Medical University

摘　　要：通过增生细胞核抗原的测定探讨幽门螺杆菌清除前后对胃粘膜上皮过度增生的影响。分别于幽门螺杆菌清除前后经胃镜取胃粘膜组织，常规免疫组化染色测增生细胞核抗原指数。结果表明：幽门螺杆菌阳性者该指数较阴性者明显增高（Ｐ＜０００１），持续阳性者该指数的变化无统计学意义；幽门螺杆菌经治疗转阴者，该指数明显下降（Ｐ＜００１）。认为幽门螺杆菌感染可致胃粘膜处于过度增生状态，是其致胃癌的主要机制。The effect of Helicobacterium pylori(HP) eradication on the proliferation of the gastric epithelium was arsessed by the expressien of the proliferating cell nuclear antigen (PCNA).Alcohol-fixed gastric biopsies taken before and after treatment for HP were immunostained with the PC-10 anti-PCAN monoclonal antibody.Results showed that the 12 patients with normal gastric mucosa and negative for HP showed a mean PCNA LI of 13.72±0.35.On the second visit,of the 56 patients initially positive for HP,40 cleared and 16 persisted with the infection.In patients who remained HP positive,the PCNA LI did no change significantly.The mean PCNA LI for those who cleared HP dicreased significantly patients who remained positive for HP on both the first and second visit,showed a significantly higher PCNA LI than normal cantral biopsies.However pationts who cleared HP infection showed a significantly higher PCNA LI only on the first visit in relaton to normal gastrie mucosa.For 8 gastric cancer patients,there was a much higherPCNA LI than those of positive for HP and normalgastric mucosa.Our studies indicate that prolonged hyperproliferation of the gastric epithelium exerted by HP infection could be a major factor for human gastric carcinogenesis.

关 键 词：胃粘膜 幽门螺杆菌 增生细胞核抗原 胃肿瘤 

分 类 号：R735.202[医药卫生—肿瘤]