MINE方案治疗复发或难治性侵袭性非霍奇金淋巴瘤患者的观察及护理  

Nursing and observation for patients with recurrent or refractory and aggressive non-Hodgkin^s lym- phoma by MINE regimen

作　　者：田园[1] 朱美仙[1] 罗盛[1] 杨爱弟[1] 林晓非[1] 

机构地区：[1]温州医学院附属第一医院血液科,325000

出　　处：《中国实用护理杂志（中旬版）》2008年第7期50-51,共2页Chinese Journal of Practical Nursing

摘　　要：目的探讨应用MINE方案治疗复发或难治性侵袭性非霍奇金淋巴瘤患者的临床观察和护理要点。方法对46例复发或难治性侵袭性非霍奇金淋巴瘤患者，化疗前护理重点为有针对性地做好心理护理，积极做好各项准备和全身情况的评估，化疗中强调预防各种并发症的发生，尤其是预防局部渗漏的发生，化疗后重点为骨髓抑制的防护及远期并发症的观察和处理。结果无一例化疗相关性死亡，感染14例，Ⅰ～Ⅱ度恶心、呕吐22例，Ⅲ度恶心、呕吐2例；Ⅰ～Ⅱ度脱发27例，Ⅰ～Ⅱ度黏膜炎4例，Ⅱ度肝功能损害1例；未出现Ⅲ～Ⅳ度心脏、肾脏毒性，未出现出血性膀胱炎。以上不良反应均经积极对症处理后好转。结论加强化疗期间针对性的心理护理，完善各项化疗准备，评估患者的状况。积极预防化疗相关并发症，可有效提高复发或难治性侵袭性非霍奇金淋巴瘤患者的化疗效果。Objective To report the clinical observation and nursing points for recurrent or refractory and aggressive non-Hodgkin＇s lymphoma treated with MINE regimen. Methods Patients （46 cases） with recurrent or refractory and aggressive non-Hodgkin＇s lymphoma were given mental nursing,preparation and evaluation of the condition of patients before chemotherapy. Complications especially extravasation of infusion fluid should be prevented during chemotherapy and myelosuppression and long-term complications should be prevented after treatment. Results No patient died after treatment but several complications such as infection（ 14 cases）, nausea and vomiting （grade Ⅰ～Ⅱ, 22 cases, grade Ⅲ,2 cases）, alopecia （grade Ⅰ～Ⅱ, 27 cases）, mucositis （grade Ⅰ～Ⅱ, 4 cases）, liver function lesion （grade Ⅱ, 1 case） were found and improved after proper treatment. No nephrotoxicity and hemorrhagic cystitis were found. Conclusions Selective mental nursing,proper chemotherapy preparation,evaluation of patients＇ condidtion and positively prevention of chemotherapy-related complications could increase the chemotherapy effect of patients with recurrent or refractory and aggressive non-Hodgkin＇s lymphoma.

关 键 词：非霍奇金淋巴瘤 化疗 护理 

分 类 号：R733[医药卫生—肿瘤] R473.6[医药卫生—临床医学]