Fas及FasL在胃癌组织非典型增生组织和正常胃粘膜中表达研究  

The Study of the Expession of Fas and FasL Protein in Gastric Carcinoma Tissues Side-carcinoma Dysplasia Tissues and Normal Gastric Mucous Membrance

作　　者：黄述斌[1] 刘振虹[2] 金小平[2] 胡亚涛[2] 梅立新[2] 

机构地区：[1]安徽省池州市人民医院病理科,安徽池州247100 [2]承德医学院病理教研室,河北承德067000

出　　处：《河北医学》2008年第8期886-888,共3页Hebei Medicine

摘　　要：目的:探讨细胞凋亡相关蛋白Fas、FasL在胃癌发生、发展中的作用。方法:应用免疫组化(S-P法)检测Fas、FasL蛋白在胃癌组织、癌旁非典型增生组织中的表达,并应用缺口原位末端标记(TUNEL染色)检测上述组织中的细胞凋亡指数(AI)。结果:Fas、FasL在胃癌及非典型增生组织中的表达显著高于正常胃粘膜(P<0.01),正常胃粘膜组织的凋亡指数显著低于非典型增生组织(P<0.01)和胃癌组织(P<0.05)。结论:Fas、FasL的异常表达可能是胃粘膜癌变过程中细胞凋亡抑制的重要机制之一,并与胃癌的免疫逃逸有关。Objective： To study the relationship between the expression of Fas and FasL protein and the pathogenosis and development of gastric carcinoma. Methods： The expression of Fas and FasL protein were detected by S -P immunohistochemistry technique . The apoptosis indexes （AI ） examed by TUNEL methods. Results： The expression of Fas and FasL in gastric carcinoma tissues and side-carcinoma dysplasia tissues are remarkably higher than that in normal gastric mucous membrance （ P 〈 0.01 ） , The apoptosis indexes of normal gastric mucous membrance are remarkably lower than that of gastric carcinoma tissues （P 〈 0. 05） and side-carcinoma dysplasia tissues （ P 〈 0.01 ）. Condusion： The abnormal expression of Fas and FasL may be involved in the pathogenesis and the immune escape of gastric carcinoma.

关 键 词：胃癌 凋亡 FAS FASL 

分 类 号：R735.2[医药卫生—肿瘤]