阳江高本底辐射对不同年龄居民染色体畸变的影响  

Cytogenetic findings from inhabitants of different ages in high background radidation areas of Yangjiang.\

作　　者：陈德清[1,2,3] 姚素艳[1,2,3] 张朝阳 戴连连 姜涛 王春燕 李曙 袁镛龄 魏履新 中井斌 菅原努 

机构地区：[1]卫生部工业卫生实验所 [2]湖南省劳动卫生研究所 [3]日本体质研究会

出　　处：《中华放射医学与防护杂志》1997年第6期386-389,共4页Chinese Journal of Radiological Medicine and Protection

摘　　要：探讨高本底辐射对人体损伤的剂量效应关系。方法从阳江高本底辐射地区（ＨＢＲＡ）选择１０，４０，５５和７０岁居民，采集外周血用微量全血培养，常规方法制备染色体标本。结果ＨＢＲＡ居民伴有断片的双着丝粒显著高于对照（ＣＡ）（０．７７‰与０．２８‰，Ｐ＜０．０１），总的结构性畸变也显示ＨＢＲＡ显著高于ＣＡ（４．６９‰与３．１５‰，Ｐ＜０．０１），并且随年龄（或累积剂量）而增加，呈线性关系。结论染色体畸变是极其灵敏的辐射损伤指征和辐射生物剂量计。Objective\ To explore the relationship between high background radiation and injurious effect on inhabitants. Method\ Peripheral blood samples were collected from the inhabitants of 10, 40, 55 and 70 years old in high background radiation areas (HBRA) of Yangjiang, Chromosome preparations were carried out with conventional whole blood microculure. Results\ The percentage of dicentric chromosome with fragments in inhabitants of HBRA was significantly higher than that in control areas (CA) (4.69‰ vs. 3.15‰, P <0.01), and there was an increase in the aberration frequencies with age (or accumulated doses). Conclusion\ Chromosome aberration is an extremely sensitive indicator of radiation damage and a good radio biodosimeter.

关 键 词：高本底辐射 染色体畸变 淋巴细胞 年龄 

分 类 号：Q345.22[生物学—遗传学] X591[环境科学与工程—环境工程]