阴茎皮肤T细胞淋巴瘤继发Fournier坏疽(1例报告)  

Primary Cutaneous T-cell Lymphoma of the Penis Complicated by Fournier Gangrene:A Case Report

作　　者：周尊林[1] 王传运[2] 徐祗顺[1] 郑宝钟[1] 

机构地区：[1]山东大学齐鲁医院泌尿外科,山东济南250012 [2]济宁市第一人民医院泌尿外科,山东济宁252500

出　　处：《中华男科学杂志》2008年第6期542-544,共3页National Journal of Andrology

摘　　要：目的:探讨阴茎皮肤T细胞淋巴瘤的临床表现、病理特点、诊断和治疗。方法:男性患者,49岁,因阴茎皮肤红斑溃破后阴茎肿胀伴发热2个月,抗感染治疗无效。包皮背侧切开术后病情无好转,并继发阴茎皮肤Fournier坏疽。再行清创引流,病变组织送病理检查。结果:病理证实为阴茎皮肤T细胞淋巴瘤,免疫组化染色CD3(++)、CD45RO(++)、CD30(-)、CD79a(-)、CD20(-)、HMB45(-)。给予干扰素和窄波紫外线治疗2周无效,出现阴茎海绵体坏死、阴囊皮肤溃烂,行阴囊内容物和阴茎全切除,病理证实海绵体和右侧睾丸受累。结论:阴茎皮肤T细胞淋巴瘤是一种罕见的阴茎部肿瘤,因早期缺乏特异性临床表现而易被误诊,病理检查是确诊依据。Objective： To explore the clinical presentation, pathologic characteristics, diagnosis and treatment of cutaneous T-cell lymphoma of the penis. Methods： A 49-year old man presented with painful swelling and inflammation of the foreskin, failed to respond to antibiotic treatment and dorsal incision, and was instead complicated by Foumier gangrene. Then he underwent debridement and pathological examination. Results ： Pathological results indicated cutaneous T-cell lymphoma of the penis. Immunohistochemistry showed CD3 and CD45 RO to be positive, but CD30, CD79a, CD20 and HMB negnative. The patient was treated by interferon alpha and ultraviolet B for 2 weeks, followed by total removal of the external genitalias because of necrosis of the corpus spongiosum, which involved the scrotum and right testis on pathological examination. Conclusion ： Cutaneous T-cell lymphoma of the penis is a rare con- dition and easily mis diagnosed in the early phase. Definitive diagnosis depends on pathological study.

关 键 词：阴茎肿瘤 阴茎皮肤T细胞淋巴瘤 Foumier坏疽 

分 类 号：R737.27[医药卫生—肿瘤] R739.5[医药卫生—临床医学]