生理条件下铜(Ⅱ)与氨基葡萄糖及α-氨基酸的配位性能  

Coordination reaction of glucosamine and α-aminoacid with copper(Ⅱ) under the physiological condition

作　　者：董丽[1] 杨洁[1] 杨志军[1] 孙祥德[1] 

机构地区：[1]河南省新乡医学院,河南新乡453003

出　　处：《化学研究与应用》2008年第7期883-886,共4页Chemical Research and Application

基　　金：河南省教育厅资助项目(No2000150018)

摘　　要：To study the coordination reactions of glucosamine and α-aminoacid with copper(Ⅱ) under the physiological condition,the pH potentiometric titration was used to determine the protonation constants of glucosamine and α-aminoacid,and the formation constants of the binary and ternary complexes of glucosamine and α-aminoacid with Cu(Ⅱ) at 37℃ with ionic strength I=0.154mol/L NaCl respectively.The results indicated that all of the protonation constants of glucosamine and α-aminoacid,and stability constant of the binary and ternary complexes of glucosamine and α-aminoacid with Cu(Ⅱ) at 37℃,I=0.154mol/L NaCl are smaller than those at 25℃ with ionic strength I=0.10 mol/L KNO3 respectively.The results also indicated that the stable ternary complex could be formed from glucosamine and α-aminoacid with copper(Ⅱ).Furthermore,the two biologically active ligand,glucosamine and α-aminoacid showed higher compatible.The stability of the ternary complexes increased with the increase of protonation constant of α-aminoacid and the stability of its binary complexes.To study the coordination reactions of glucosamine and α-aminoacid with copper（Ⅱ） under the physiological condition, the pH potentiometric titration was used to determine the protonation constants of glucosamine and α-aminoacid, and the formation constants of the binary and ternary complexes of glucosamine and α-aminoacid with Cu （Ⅱ） at 37℃ with ionic strength I = 0. 154mol/L NaCl respectively. The results indicated that all of the protonation constants of glucosamine and α-aminoacid, and stability constant of the binary and ternary complexes of glucosamine and α-aminoacid with Cu（Ⅱ） at 37℃, I =0. 154mol/L NaCl are smaller than those at 25℃ with ionic strength I = 0. 10 mol/L KNO3 respectively. The results also indicated that the stable ternary complex could be formed from glucosamine and α-aminoacid with copper（Ⅱ）. Furthermore, the two biologically active ligand, glucosamine and α-aminoacid showed higher compatible. The stability of the ternary complexes increased with the increase of protonation constant of α-aminoacid and the stability of its binary complexes.

关 键 词：氨基葡萄糖 Α-氨基酸 铜(Ⅱ) 配合物 稳定性 生理条件 

分 类 号：O614.33[理学—无机化学]