热疗联合腔内化疗治疗恶性胸腹腔积液52例  

Effective Observation of Hyperthermia Combined with Intracavitary Chemotherapy for Malignant Splanchnocoel Effusion

作　　者：杨岩丽[1] 李洪云[1] 姜伟[1] 

机构地区：[1]山东铝业公司医院肿瘤科,山东淄博255069

出　　处：《湖北民族学院学报（医学版）》2008年第2期57-59,共3页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的探讨热疗联合腔内化疗治疗恶性胸腹腔积液的临床疗效、毒副反应及对肿瘤患者生活质量的影响。方法52例恶性胸腹腔积液患者,先行胸腹腔穿刺置管引流排尽积液后,以顺铂单药或联合氟尿嘧啶二联化疗药物行腔内注射,每次腔内注药化疗后1 h内行射频热疗,治疗温度控制在40℃-42℃,并维持30-60 min。结果52例恶性胸腹腔积液患者中,胸腔积液患者35例,其中CR20例,PR11例,有效率88.6%;腹腔积液患者17例,其中CR4例,PR7例,有效率64.7%。治疗后患者的KPS评分均有不同程度升高。与热疗相关的主要毒副作用为局部皮肤灼痛9例（17.3%）,皮下脂肪硬结5例（9.6%）,皮肤灼伤3例（5.8%）,心悸3例（5.8%）。结论热疗作为一种杀灭肿瘤细胞的有效方法,与化疗联合治疗恶性胸腹腔积液可取得较好的临床疗效,明显改善患者的临床症状及生活质量,毒副作用可以耐受。Objective To evaluate the efficacy and toxicity of hyperthermia with intraperitoneal chemotherapy for patients with malignant splanchnocoel effusion.Methods Fifty-two cancer patients with malignant splanchnocoel effusion were studied,after malignant splanchnocoel effusion was extracted,they were treated by intracavitary infusion of DDP or DDP ＋ Fluorouracil,and then underwent hyperthermia in one hour.The therapy time lasted for 30～60 minutes,and the temperature of skin maintain 40℃～42℃.Results Among 35 pleural effusion patients,20 cases were obtained complete response（CR）,11 cases were obtained partly response（PR）,effective rate was 88.6%;Among 17 seroperitoneum patients,4 cases were obtained complete response,7 cases were attained partly response,effective rate was 64.7%.The Karnofsky score（KPS）was increased after treatment.The main toxicity of hyperthermia had focal skin causalgia（7.3%）,indurations of subcutaneous fat（9.6%）,skin scorch（5.8%）,cardiopalmus（5.8%）.Conclusion Hyperthermia combined with intraperitoneal chemotherapy for patients with malignant splanchnocoel effusion is an effective therapeutics method which can improve the quality of life and the side effects are tolerable.

关 键 词：热疗 腔内化疗 恶性胸腹腔积液 

分 类 号：R730.5[医药卫生—肿瘤]