急性白血病患者化疗前后IL-2及IL-6水平测定的临床意义  

Clinical significance of test on levels of IL-2 and IL-6 for AL patients before and after chemotherapy

作　　者：张雄[1] 肖玉梅[1] 刘传勇[1] 古茂群[1] 廖丽娟[1] 

机构地区：[1]广东省茂名市人民医院血液科,广东茂名525000

出　　处：《中国卫生检验杂志》2008年第7期1372-1373,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨急性白血病患者化疗前后白介素-2(IL-2)及白介素-6(IL-6)水平变化对免疫功能影响的临床意义。方法:应用放射免疫分析法对57例急性白血病患者进行化疗后血清IL-2及IL-6含量检测,并与30例正常健康人作对照。结果:急性白血病初治组及短期完全缓解(CR)组IL-2水平分别为(18.69±9.41)ng/L,(29.36±6.30)ng/L,明显低于长期CR组(46.71±8.23)ng/L及正常对照组(53.62±8.86)ng/L;初治组及短期CR组IL-6水平分别为(125.86±15.78)ng/L,(82.27±10.21)ng/L,明显高于长期CR组(30.29±7.63)ng/L及正常对照组(23.46±6.32)ng/L。初治组IL-2和IL-6水平与长期CR组及正常对照组比较差异有显著性,P<0.05。结论:初治及短期CR急性白血病患者IL-2水平低、IL-6水平高,造成免疫抑制状态,白血病易复发。随着CR时间的延长,免疫状态逐渐恢复。Objective：To probe into the clinical significance of influence of the changes of interleukin（IL） -2 and IL- 6 on immune function of acute leukemia （AL） patients before and after chemotherapy. Methods： With the radio - immuno - assay （RIA） used, the contents of IL- 2 and IL-6 in the serum of 57 cases AL patients after chemotherapy were tested, which had been compared with 30 cases healthy persons. Results ： The levels of IL - 2 in AL initial treatment group and short - term complete relief （CR） group were respectively （ 18.69 ± 9.41 ） ng/L and （29. 36 ± 6. 30） ng/L, which were obviously lower than those in long -term CR group （46. 71 ±8.23） ng/L and healthy control group （53.62 ± 8.86） ng/L. The levels of IL - 6 in AL initial treatment group and short - term CR group were respectively （ 125.86 ± 15.78） ng,/L and （82. 27 ± 10.21 ） ng,/L, which were obviously higher than those in long - term CR group （ 30. 29 ± 7.63 ） ng/L and healthy control group （23.46 ± 6. 32） ng/L. The levels of IL - 2 and IL - 6 in initial treatment group had significant differences comparing with those in long - term CR group and healthy control group （P 〈 0.05）. Conclusion：Of the AL patients in initial treatment group and short -term CR group, the level of IL - 2 is low and IL - 6 is high, by which the immuno - suppression condition will be formed and the AL is easy to recur. With the extending of CR time, the immune condition will gradually recover.

关 键 词：白血病 完全缓解期 白介素-2 白介素-6 免疫功能 

分 类 号：R733.71[医药卫生—肿瘤]