二丙酸倍氯米松治疗溃疡性结肠炎的疗效及对P-选择素、ICAM-1表达影响研究  

A Study of Beclomethasone Dipropionate in the Treatment of Ulcerative Colitis and Regulating Effect on P-selectin and ICAM-1 Expression

作　　者：张运贵[1] 张瑞玲[1] 黄咏梅[1] 张树民[1] 张新铭[1] 薛强[1] 

机构地区：[1]济南市第四人民医院,济南250031

出　　处：《临床消化病杂志》2008年第3期176-178,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨二丙酸倍氯米松灌肠治疗溃疡性结肠炎(UC)的临床疗效及对P-选择素、ICAM-1表达的影响,探讨其治疗UC的价值。方法将58例活动期UC患者随机分为2组:治疗组和对照组,均口服美沙拉嗪作为基础治疗。治疗组(n=32)采用二丙酸倍氯米松保留灌肠;对照组(n=26)应用氢化可的松保留灌肠。结果治疗组总有效率高于对照组(93.75%vs80.77%),但差异无显著性(P>0.05)。P-选择素、ICAM-1表达强度与炎症程度有关(P均<0.01),二丙酸倍氯米松组治疗后其表达程度明显减弱(P<0.01),而氢化可的松组无明显下降(P>0.05)。结论二丙酸倍氯米松保留灌肠治疗溃疡性结肠炎有较好疗效,下调组织中黏附分子的表达是其作用机制之一。Objective To determine the effect of beclomethasone dipropionate in the treatment of ulcerative colitis （UC） and regulating effect on P-selectin and ICAM-1 expression. Methods 58 patietns with ulcerative colitis were classified randomly into 2 groups. Among them, 32 patients were treated with retention enema of beclomethasone dipropionate and 26 patients with corticosteroids as control. Expression of P-selectin and ICAM-1 were detected by S-P immunohistochemical method before and after treatment. Results The effect of clinical symptoms and endoscopical change were better in treatment group than that in control group ,but there was no statistical significance. The overexpression of P-selectin and ICAM-1 was found in both groups before treatment and beclomethasone dipropionate could descend both of them. Conclusion Beclomethasone dipropionate is an effective medicine in treatment of UC and downregulating the expression of its mechanism.

关 键 词：溃疡性结肠炎 二丙酸倍氯米松 P-选择素 组织间黏附分子(ICAM-1) 

分 类 号：R574.62[医药卫生—消化系统]