核素骨显像对内分泌治疗前列腺癌骨转移疗效的观察  

Radionuclide bone imaging in the evaluation of the effect of endocrinotherapy on prostate cancer with bone metastasis

作　　者：冯勇[1] 胡颖坚[1] 何红园[1] 张汝森[1] 

机构地区：[1]广州市红十字会医院核医学科,广东广州510220

出　　处：《广东药学院学报》2008年第3期316-318,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的研究放射性核素骨显像在内分泌治疗前列腺癌骨转移的应用价值。方法对36例前列腺癌骨转移患者内分泌治疗前后进行全身骨显像并分析骨转移灶数目,同时测定血清前列腺特异性抗原(PSA)的浓度。结果前列腺癌骨转移患者内分泌治疗后根据骨转移灶的数目将骨显像表现可分为3种类型:减少或消失;保持稳定状态;增多;每一类型伴有相应的血清PSA变化规律。结论放射性核素骨显像可直观地监测骨转移灶的变化,是监测疗效的必要手段,可弥补血清PSA作为内分泌治疗前列腺癌疗效评价指标的不足。Objective To evaluate the radionuelide bone imaging in the evaluation of the effect of endocrinotherapy on prostate cancer with bone metastasis. Methods 36 cases of prostate cancer with bone metastasis were measured with radionuclide bone imaging before and after endoerinotherapy. The PSA tests were taken at the same time as control. Imaging findings were measured and analyzed. Results There were 3 types of bone metastasis changes according to different reactions to the endoerinotherapy： decreased or disappeared; Stable; augmented. Each change was matched to the PSA change. Conclusions Radionuclide bone imaging can monitor the change of bone metastasis directly and easily. And it has the same importance as PSA in the evaluation of the effect of enderinotherapy in prostate cancer with bone metastasis.

关 键 词：前列腺癌 放射性核素 骨显像 骨转移 内分泌治疗 

分 类 号：R737.25[医药卫生—肿瘤]