脂氧合酶抑制剂的研究进展  

Advances in the research of lipoxygenase inhibitors

作　　者：朱宏翔[1] 胡建安[1] 

机构地区：[1]中南大学公共卫生学院劳动卫生与环境卫生学系,长沙410078

出　　处：《中南大学学报（医学版）》2008年第6期541-547,共7页Journal of Central South University ：Medical Science

摘　　要：脂氧合酶是一类广泛存在于动植物中的非血红素铁蛋白,其对内源性多不饱和脂肪酸双加氧作用产生的白三烯等生物活性因子和对外源化学物协同氧化酶活性的氧化活化产物,与人体的肿瘤、炎症、哮喘、动脉硬化等疾病以及化学物的毒作用密切相关。脂氧合酶抑制剂有异羟肟酸类、去甲二氢愈创木酸类、黄酮类和脂氧合酶激活蛋白抑制剂,他们均能有效地抑制脂氧合酶的代谢活性;研究证明这些抑制剂能抑制有关活性因子和毒性产物的产生,临床应用能防治有关疾病,保护人体健康。Lipoxygenase is a protein with non-heme iron atom,which has been discovered in many animals and plants.Lipoxygenase which has a close relationship with human tumors,inflammatory diseases,asthma,arteriosclerosis,and toxic action of chemicals could not only di-oxygenate endogenous polyunsaturated fatty acid to yield bioactive factors such as leukotrienes（LTs）,but also has co-oxidation activity to activate xenobiotics.Lipoxygenase inhibitors include hydroxamic acid derivatives,nordihydroguaiaretic acid,flavonoids,FLAP inhibitors and so on.All of them can effectively restrain the catalytic action of lipoxygenase.Literatures demonstrate that the inhibitors can block the formation of relevant bioactive factors and toxic products of xenobiotics clinically which are used to prevent and cure the relevant diseases to keep people healthy.

关 键 词：脂氧合酶 氧化还原 抑制剂 

分 类 号：R965[医药卫生—药理学]