兔视网膜下非活动视觉假体载片植入对ERG的影响  

The effect of subreinal inactive chips on electroretinography in rabbit retina

作　　者：刘芳[1] 刘武[1] 刘守彬[1] 莫宾[1] 李倩[1] 李翔[1] 

机构地区：[1]首都医科大学附属北京同仁医院眼科中心,北京100730

出　　处：《眼科研究》2008年第7期498-500,共3页Chinese Ophthalmic Research

基　　金：国家自然科学基金资助(30571989)

摘　　要：目的用视网膜电图(ERG)探究视网膜下非活动视觉假体载片植入对视网膜功能的影响。方法24只新西兰白兔,随机分为手术组和伪手术组(各12只兔)。记录各组术前及术后7、15、30、60d(每时间点3只兔)ERGb波振幅。统计各组ERG的a波和b波振幅数值,进行t检验和单因素方差分析。结果各组间及手术组、伪手术组时间点间ERGa波振幅未见明显差异。手术组术后ERGb波振幅较术前正常对照组有不同程度升高(P=0.038),手术组与伪手术组间及伪手术组与术前正常对照组间差异无统计学意义(P=0.649和P=0.369),手术组和伪手术组时间点间差异无统计学意义。结论手术组视网膜下非活动视觉假体载片植入后ERGb波振幅有不同程度的升高,提示载片植入后在一定时间范围内可能保护视网膜的功能。Objective The implantation of subreinal prosthesis in the patients with blindness caused by retinitis pigmentosa and age-related macular degeneration have been reported. But the evaluation result of the visual function after implantation of retinal prosthesis is less seen. In this study, subretinal inactive chip was implanted in rabbit retina to evaluate the effect of subretinal inactive chip on electroretinography. Methods Twenty-four New Zealand white rabbits were randomly divided into operated group and sham-operated group（ 12 rabbits for each group）. The inactive chips was implanted subretinally in operative group, and in the sham-operated group, implanted chips was removed during operation. The a-wave and b-wave amplitudes of electroretinogram（ERG） in operated group and sham-operated group were recorded and analyzed before and 7,15, 30 and 60 days（3 rabbits for each time point） after surgery. Results The b-wave amplitudes of operated group were higher to different degrees than that of normal control group in various time points （ P = 0. 038 ）. And no significant difference in b-wave amplitudes between sham-operated group and operated group was determined （P = O. 649）. The difference of h-wave amplitudes between the sham-operated group and normal control group（ P = 0. 369） or the difference of a-wave amplitudes between these two groups were not statistically significant too. Conclusion The elevations of b-wave amplitudes in rabbits in operation group impliy that the retinal function can be improved after subretinal inactive chips implantation.

关 键 词：视网膜下假体 视网膜电图 机械损伤 兔 

分 类 号：R774.1[医药卫生—眼科]