蛋白酶体抑制剂对面神经运动神经元的保护作用  

Protective effect of proteosome inhibitor on motoneurons after facial nerve axotomy

作　　者：刘南[1] 周柏玉[1] 王静[1] 

机构地区：[1]解放军第451医院神经内科,陕西西安710054

出　　处：《第四军医大学学报》2008年第13期1160-1162,共3页Journal of the Fourth Military Medical University

摘　　要：目的:观察面神经损伤局部使用蛋白酶体抑制剂MG132对面神经运动神经元的保护作用.方法:制作大鼠面神经切断模型,12只大鼠随机分为治疗组与对照组,治疗组大鼠在面神经损伤同时局部使用MG132,而对照组则给予生理盐水.术后观察面神经运动神经元的存活情况,并使用CTB逆标的方法观察面神经元轴突变性的情况.结果:给予蛋白酶体抑制剂MG132可以增加面神经损伤后面神经运动神经元存活数目(P<0.05),且CTB逆标面神经元的数目也增加(P<0.05).结论:蛋白酶体抑制剂MG132对损伤面神经具有保护作用.AIM： To investigate the protective effect of proteosome inhibitor MG132 on the survival of motoneurons after facial nerve axotomy. METHODS： Twelve rats injured with facial nerve axotomy were randomly divided into experimental and control groups. In the experimental group, proteosome inhibitor MG- 132 was administrated directly to the lesion site, while in the control group, isotonic Na chloride was injected instead. The facial nerve and motoneurons were stained by HE and retrogradely labeled by CTB. RESULTS： The numbers of survival and retrogradely labeled facial nerve motoneurons were both significantly higher in the MG132 treatment group than in the control group （ P 〈 0. 05 ）. CONCLUSION： MG132 can alleviate the axonal degeneration and promote the motoneurons survival after facial nerve axotomy.

关 键 词：面神经损伤 蛋白酶体抑制剂 神经纤维 凋亡 

分 类 号：R745.12[医药卫生—神经病学与精神病学]