羟考酮控释片联合甲地孕酮治疗晚期癌痛的临床观察  

The Effect of Controlled-release Oxycodone Combined with MEGACE Relieves Pain with Advanced Carcinoma

作　　者：凌华海[1] 欧雪萍[1] 陈焕伟[1] 

机构地区：[1]广东省农垦中心医院,广东湛江524002

出　　处：《宁夏医学杂志》2008年第7期600-601,共2页Ningxia Medical Journal

摘　　要：目的观察羟考酮控释片联合甲地孕酮治疗晚期癌痛疗效和改善生活质量的作用。方法64例晚期癌痛患者随机分为观察组32例、对照组32例。观察组:羟考酮控释片联合甲地孕酮。对照组单纯用羟考酮控释片。结果KPS评分改善观察组有效率为68.8%,对照组为59.4%,两组比较差异无统计学意义(χ2=0.61,P>0.05),但显效率比较有统计学意义(χ2=4.50,P<0.05)。另外观察组食欲及体重改善情况明显优于对照组,两组不良反应相似。结论羟考酮控释片联合甲地孕酮治疗晚期癌痛,对缓解癌痛和改善生活质量取得了较好疗效,值得在临床上进一步推广。Objective To evaluate the efficacy of controlled -release oxycodone combined with MEGACE relieves in patients with advanced carcinoma pain, and observe the improvement of quality of life （QOL）. Methods Total of 64 patients with advanced carcinoma pain randomly assigned into two groups ： One group were treated by controlled - release oxycodone combined with MEGACE, The other group was given controlled - release oxycodone alone. Results Two groups achieved effective rate of relieves pain with advanced carcinom Were 90.6% and 84.4% ,No statistical significant difference was noted in responses between the two groups, P 〉 0.05. Two groups achieved effective rate of the score of Karnofsky were 68.8% and 59.4%, No statistical significant difference was noted in responses between the two groups ,P 〉 0.05. but significant efficiency were statistical significant difference in responses between the two groups, P 〈 0.05. Improvement of appetite and gained weight in the testing group were obviously difference in the control group, the toxicity reactions were similar in two groups. Conclusion Controlled - release oxycodone combined with MEGACE can beneficial effects to relieves carcinoma pain and improve quality of life in patients with advanced carcinoma , It deserve further testing in the clinical.

关 键 词：羟考酮控释片 甲地孕酮 晚期癌痛 生活质量 

分 类 号：R730.53[医药卫生—肿瘤]