清洁级、SPF级SD大鼠血液生理、生化测定与比较  

Comparison of Blood Physiology and Biochemistry between SPF and Ordinary-level SD Rat

作　　者：杨锋[1] 王红星[1] 何永亮[1] 余晓君[1] 苏立建[1] 

机构地区：[1]四川省医学科学院.四川省人民医院实验动物研究所,成都610212

出　　处：《四川动物》2008年第4期648-650,共3页Sichuan Journal of Zoology

摘　　要：目的测定清洁级、SPF级SD大鼠血液生理、生化指标并进行比较,了解不同环境SD大鼠血液生理、生化指标的差异。方法利用法国产BASIC半自动血液生化分析仪和意大利产HS-18全自动血球计数仪对不同环境SD大鼠10项血液生化值和18项血液常规值进行测定。结果清洁级、SPF级SD大鼠葡萄糖(GLU)、总胆固醇(TC)、白细胞(WBC)、血红蛋白(HGB)、平均红细胞血红蛋白浓度(MCHC)、血小板(PLT)、血小板比积(PCT)、血小板平均体积(MPV)比较有非常显著差异;丙氨酸氨基转移酶(ALT)、红细胞(RBC)比较有极显著差异;红细胞比积(HCT)比较有显著差异。结论不同环境对SD大鼠血液生理、生化测定结果有较大影响。Objective To evaluate the indices of blood physiology and biochemistry between ordinary-level and SPF rat. Method 10 biochemistry and 18 counts of cell blood of SD-brand rat were detected under different conditions, using BAS- IC half-automatic biochemistry analyzer （made in France） and HS-18 automatic blood cell counter （made in Italy）. Results Between ordinary-level and SPF SD rat, the indices of GLU, WBC, MCHC, PLT, PCT, MPV differ remarkably; ALT and RBC differ considerably, while HCT differs comparatively. Conclusion Different conditions affect blood physiology and biochemistry of SD rat greatly.

关 键 词：SD大鼠 血液生理 血液生化 

分 类 号：R-332[医药卫生]