利用三种方法计算眼屈光度的遗传度  

Calculation of the heritability of the refractive error by three different methods

作　　者：秦雪娇[1] 陈红梅[1] 李镜海[1] 

机构地区：[1]山东大学齐鲁医院眼科,济南250012

出　　处：《山东大学学报（医学版）》2008年第7期720-724,共5页Journal of Shandong University:Health Sciences

基　　金：教育部留学回国人员科研启动基金资助项目(2005);山东省优秀中青年科学家科研奖励基金(2007BS03056)

摘　　要：目的将屈光度作为一连续性计量型变量，计算其遗传度。方法以一个爱尔兰大家系为随机样本，分别用均父母-子代回归系数法、单亲-子代回归系数法及序贯性寡基因连锁分析系统（SOLAR）3种方法，以屈光度的原始测量值及行正态转换后的数值来计算屈光度的遗传度。结果15对完整的双亲-子代数据用于均父母-子代回归法分析，以屈光度的测量数据和正态转换数据算得的遗传度分别为0．56和0．60（标准误分别为0．16和0．17）；24对完整的单亲-子代数据用于单亲-子代回归法，以屈光度的测量数据和正态转换数据算得的遗传度分别为0．14和0．28（标准误分别为0．11和0．17）；137例有效数据用于SOLAR分析，以屈光度的测量数据和正态转换数据算得的遗传度分别为0．52和0．57（标准误分别为0．16和0．16），年龄作为共变量作用无统计学意义。结论以屈光度作为连续性计量资料分析得到的研究样本的遗传度在0．5～0．6左右，说明遗传因素在屈光系统的形成中起着一半以上的作用。均父母-子代回归法和序贯性寡基因连锁分析系统法对屈光度的遗传度的计算较单亲-子代回归法可靠。Objective To calculate the heritabihty of the refractive error serves as a continuous quantitative variable. Method A large Irish family was used as a random sample. Heritability was calculated by mid-parent-offspring regression, parent-offspring regression and sequential oligogene linkage analysis routine （SOLAR） methods. The original refractive data and the data obtained after normality-transformation were separately calculated. Result In total we got 15 pairs numbers for mid-parent-offspring regression, 23 pairs for parent-offspring regression, and 137 numbers for SOLAR calculation. Heritabilities in the original refractive data and transformed data from the three methods were as follows： 0.56 and 0.60 for mid-parent-offspring regression （Standard Error： 0.16 and 0.23）, 0.14 and 0.28 for parent-offspring regression （Standard Error： 0.11 and 0.17）, and 0.51 and 0.57 for SOLAR （Standard Error： 0.16 and 0.16）. Age served as a covariate which had no significant result. Conclusion The heritability of the refractive error in our sample was 0.5-0.6, which means that genetic factors accounted for about haft of the efficiency for refractive error. We think that heritability calculated by mid-parent-offspring regression and SOLAR is more reliable than that calculated by parent-offspring regression.

关 键 词：遗传度 屈光不正 屈光 眼 回归分析 序列分析 

分 类 号：R778[医药卫生—眼科] R394[医药卫生—临床医学]