间歇性雄激素阻断治疗晚期前列腺癌效果观察  

Curative effect of intermittent androgen deprivation treatment for advanced prostate cancer

作　　者：吴洋[1] 胡云飞[1] 胡俊丹[1] 孙刚[1] 

机构地区：[1]武汉大学人民医院泌尿外科,430060

出　　处：《临床外科杂志》2008年第7期474-476,共3页Journal of Clinical Surgery

摘　　要：目的评价间歇性雄激素阻断治疗晚期前列腺癌的可行性及优点。方法选取晚期前列腺癌患者59例,随机分为2组。给予间歇性雄激素阻断治疗30例(A组),给予持续雄激素阻断治疗29例(B组),观察两组患者的疾病进展及治疗期间副反应的发生情况,比较两种方法的治疗效果。结果A组患者平均随访26个月,B组患者平均随访27个月,两组患者疾病进展情况未见明显差异。A组患者副反应低于B组患者且能在治疗间歇期得到缓解。结论间歇性雄激素阻断治疗方法可行,能够减少患者治疗的副反应,提高患者生活质量。Objective To explore the possibility and advantage of intermittent androgen deprivation （IAD） for patients with advanced prostate cancer. Methods In 59 patients with advanced prostate cancer,30 （group A） were treated with IAD and the remaining 29 patients （group B） with continuous androgen deprivation （CAD）. The disease progression and the side effect of two groups were observed. Results There was no siginificant difference between two groups in the progression of the disease. The incidence of the side effect was lower in group A than in group B and side effects could be alleviated during off - treatment period in group A. Conclusion IAD is feasible, and can reduce side effects and raise the quality of life of the patients with advanced prostate cancer.

关 键 词：前列腺肿瘤 间歇性雄激素阻断治疗 副反应 

分 类 号：R737.25[医药卫生—肿瘤]