原发性肝癌TACE前后血清VEGF与CT灌注参数间相关性的研究  

Correlation Between Serum VEGF Level and CT Perfusion Parameters Before and After TACE in Patients with Hepatocellular Carcinoma

作　　者：陈光斌[1] 邹文远[1] 张自力[1] 石思李[1] 张桂华[1] 顾永丽[1] 蔡庆和[2] 李金科[3] 聂森[1] 唐先志[1] 王家宁[4] 郭凌云[4] 

机构地区：[1]湖北省郧阳医学院附属人民医院放射科,442000 [2]湖北省郧阳医学院附属人民医院肝胆外科,442000 [3]湖北省郧阳医学院附属人民医院肝病科,442000 [4]湖北省郧阳医学院附属人民医院临床医学研究所,442000

出　　处：《临床放射学杂志》2008年第7期908-910,共3页Journal of Clinical Radiology

基　　金：湖北省教育厅科研项目(编号:B200524015)

摘　　要：目的探讨原发性肝癌（HCC）患者TACE前后血清血管内皮生长因子（VEGF）水平和CT灌注参数之间的关系。资料与方法对17例HCC患者于TACE术前1天及术后7~10天测量血清VEGF水平,同时行CT灌注扫描,计算肝血流量（HBF）、肝动脉灌注分数（HAF）,肝动脉灌注量（HAP）、门静脉灌注量（PVP）。结果原发性肝癌TACE前后HBF、HAP差异有统计学意义,血清VEGF与HBF、HAF、HAP呈正相关。结论血清VEGF水平及CT灌注可帮助评价肝癌TACE疗效。Objective To investigate correlation between serum level of vascular endothelial growth factor（ VEGF） and CT perfusion parameters （CTPP） before and after transcatheter hepatic arterial chemoembolization （TACE） in patients with hepatocellular carcinoma （HCC）. Materials and Methods The serum level of VEGF was measured and CT perfusion was performed 1 day before treatment and from 7 to 10 day after TACE in 17 patients with HCC. The values of hepatic blood flow （HBF） ,hepatic arterial fraction （HAF） ,hepatic arterial perfusion （HAP） , portal vein perfusion（PVP） were calculat- ed. Results There was statistically significant difference in HBF and HAP between that of pretreatment and posttreat- ment. There was positive correlation between the serum level of VEGF and HBF, HAF, and HAP..Conclusion The serum level of VEGF and CTPP could be helpful in the evaluation of the therapy effect of TACE.

关 键 词：肝细胞癌 经肝动脉栓塞化疗术 血管内皮生长因子 灌注 体层摄影术 X线计算机 

分 类 号：R735.7[医药卫生—肿瘤]