降钙素基因相关肽对血栓形成后大鼠离体腹主动脉的舒张作用  

Effect of calcitonin gene-related peptide on relaxation of isolated abdominal aorta of rat following thrombosis

作　　者：徐晖[1] 朱妙章[1] 韩海潮[2] 裴建明[1] 王跃民[1] 臧益民[1] 胡三觉[1] 

机构地区：[1]第四军医大学生理学教研室,西安710033 [2]西安交通大学生物力学研究室

出　　处：《第四军医大学学报》1997年第6期532-535,共4页Journal of the Fourth Military Medical University

基　　金：日本Uchida国际研究基金;国家教委优秀年轻教师基金

摘　　要：观察外源性降钙素基因相关肽（CGRP）对血栓形成后大鼠腹主动脉环舒张效应以及CGRP拮抗剂CGRP（8－37）对CGRP效应的影响．方法：利用离体血管灌流技术．结果：CGRP对血栓形成的大鼠腹主动脉舒张作用增强，在10-10～10-6mol／L范围内，CGRP对血栓组、肝素抗凝组和正常对照组大鼠腹主动脉均有舒张作用，并呈现浓度依赖性，其中对血栓组的舒张作用最为显著，最大舒张百分数（Rmax）为（56．32±10．92）％．CGRP（8－37）可拮抗正常及血栓组腹主动脉内源性CGRP的作用．结论：提示CGRP可能是血管系统中的非胆碱能和非肾上腺素能递质．血栓形成局部血管壁CGRP1受体密度和（或）CGRP纤维分布可能改变．The effects of exogenous CGRP on the isolated abdominal aorta rings of rat following thrombosis and competitive antagonist CGRP(8-37) on CGRP-induced relaxation were observed. Methods: Vitro vessel perfusion method. The thrombosis was induced to rat abdorninal aorta by endothelium denudation with a polyethylene catheter combining severe stenosis. Results: The relaxing response of CGRP on the local vessel of abdominal aorta after thrombosis was increased, CGRP had a dose-dependent relaxation on murine abdominal aorta of the control group, heparin group and thrombosis group in the concentration range of 10-10～10-6mol/L. Among them the effect on abdorninal aorta of the thrombosis group was the most significant, its maximum relaxing effect was (56. 32±10. 92) %. CGRP(8-37) blocked endogenous CGRP-induced relaxation in the control and thrombosis group. Conclusion: CGRP might be a noncholonergic arid nonadrenergic transmitter. There might be changes of CGRP1 receptor and CGRP-immunoreactive fibre in abdominal aorta following thrombosis.

关 键 词：动脉 血栓形成 CGRP 舒张血管作用 辣椒素 

分 类 号：R543.502[医药卫生—心血管疾病] R364.15[医药卫生—内科学]