果蝇Bag-of-marbles在生殖干细胞分化及配子发生中的作用  

Roles of the Bag-of-marbles of Drosophila in the Differentiation of Germline Stem Cell and the Gametogenesis

作　　者：王士友[1] 张耀洲[1] 

机构地区：[1]浙江理工大学生命科学学院生物化学研究所,杭州310018

出　　处：《细胞生物学杂志》2008年第3期329-332,共4页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展规划(973计划)(No.2005CB121006);国家科技支撑计划项目(No.2006BAI01B04);国家自然科学基金(No.30670095);浙江省自然科学基金重点项目(No.Z204267)~~

摘　　要：Bam(bag-of-marbles)是果蝇两性配子发生过程中的一个调节因子,与其他已知的蛋白质没有明显的同源关系。自1990年在果蝇中克隆了bam基因以来,至今还没有在其他物种中发现此基因。研究发现,Bam在两性配子发生过程中行使不同的功能。在雌性果蝇中,Bam不仅调节生殖干细胞到包囊母细胞的分化,而且还参与包囊母细胞的不完全胞质分裂;在雄性果蝇中,Bam参与调节精原细胞从有丝分裂向减数分裂的转换。Bag-of-marbles （Barn） is a regulatory factor during gametogenesis in Drosophila, which shows no significant homology to other known proteins. The bam gene has not been identified in other species since it was cloned from Drosophila in 1990. Recent researches show that Barn plays different roles in oogenesis and spermatogenesis. In female Drosophila, Bam regulates the differentiation from the germline stem cell to cystoblast, and also promotes incomplete cytokinesis in the cystoblast. However, in male Drosophila, Bam is responsible for the transition of spermatogonium from mitosis to meiois.

关 键 词：BAM 生殖干细胞 分化 

分 类 号：Q25[生物学—细胞生物学]