胃癌血管生成及抗血管生成治疗的研究进展  

Advances in gastroma angiogenesis and antiangiogenesis treatment for gastric carcinoma

作　　者：付彦超[1] 张庆瑜[1] 

机构地区：[1]天津医科大学总医院消化科,天津市300052

出　　处：《世界华人消化杂志》2008年第18期2012-2018,共7页World Chinese Journal of Digestology

基　　金：天津市自然科学基金资助项目;No.07JCZDJC07700~~

摘　　要：作为肿瘤间质组成的一部分,肿瘤内血管生成不仅为原发肿瘤生长所必需,也是肿瘤细胞向远处播散的必备条件之一.超微结构和免疫组化的观察发现,不同人类肿瘤组织中的血管密度和数量与肿瘤的侵袭转移潜能密切相关.最近许多研究证实了血管生成与胃癌侵袭性之间的联系,同时也有许多研究证实抑制血管生成能显著抑制肿瘤的生长及转移,在胃癌的治疗实验中已初步显示出良好的应用前景.As a component of tumor stroma, tumor angiogenesis is not only essential to primary tumor growth but also one of the requisites to disseminate. Ultrastructural organization and immunohistochemisty have shown that density and quantity of blood vessels has a close association with the potentiality of tumor invasion and metastasis. Some recent studies confirm correlation between angiogenesis and invasion of gastric tumor, and some other studies prove that antiangiogenesis can significantly inhibit tumor growth and metastasis, which has demonstrated a promising application perspective for gastric carcinoma treatment.

关 键 词：胃癌 血管生成 血管生成抑制 

分 类 号：R735.2[医药卫生—肿瘤]