胰腺导管内乳头状黏液性肿瘤研究进展  

Advances in pancreatitic intraductal papillary mucinous neoplasms

作　　者：王伟[1] 李兆申[1] 高军[1] 

机构地区：[1]中国人民解放军第二军医大学附属长海医院消化内科,上海市200433

出　　处：《世界华人消化杂志》2008年第18期2025-2030,共6页World Chinese Journal of Digestology

摘　　要：胰腺导管内乳头状黏液性肿瘤(pancreatic intraepithelial neoplasias,IPMNs)是新近被认识的一种胰腺囊性肿瘤.在不同类型胰腺肿瘤中,IPMNs预后相对较好,具有与一般胰腺肿瘤不同的分子及临床病理特征;按照乳头状结构及黏蛋白的表达又可将其分为多个亚型,不同亚型又具有不同的病理特点.病理学家提出IPMNs是胰腺癌发生过程中的重要阶段,深入研究IPMNs及其不同亚型的病理特点及其所蕴含的分子变化,将能更好的揭示IPMNs的发病机制及生物学特征.本文回顾相关文献,从分子特征、病理特征、诊断治疗及预后判断等不同角度对目前IPMNs的研究进展作一综述.Intraductal papillary mucinous neoplasms （IPMNs） are a well-characterized group of intraductal mucin-producing cystic neoplasms of pancreas with clear malignant potential. It has a favorable prognosis and distinct molecular or clicinopathologic features compared with other types of pancreatic tumors. In addition, IPMNs can be divided into several subtypes in accordance with the papillary structure and mucin expression profile. Importantly, as IPMNs are acknowledged as key stages during pancreatic carcinogenesis, it can better reveal the mechanism and biological characteristics of IPMNs through further investigation of the pathologic features and the molecular aberrations harbored in different subtypes of IPMNs. This paper reviewed relevant literatures and elucidated its progression in terms of the molecular and clicinopathologic characteristics, diagnosis, treatment and prognosis of IPMNs.

关 键 词：上皮内瘤变 导管内乳头状黏液性肿瘤 胰腺导管腺癌 黏液性囊性瘤 

分 类 号：R735.9[医药卫生—肿瘤] R735.2[医药卫生—临床医学]