TGF-β/CTGF在肠纤维化机制中的作用  

Roles of TGF-β/CTGF in intestinal fibrosis

作　　者：安彩萍[1] 马晓芃[1] 吴焕淦[1] 刘慧荣[1] 施征[1] 

机构地区：[1]上海市针灸经络研究所,上海市200030

出　　处：《世界华人消化杂志》2008年第19期2137-2143,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30400609;上海市重点学科(针灸推拿学)资助项目;No.T0302上海市青年科技启明星资助项目;No.06QA14049~~

摘　　要：肠纤维化是多种炎性肠病比较棘手的并发症,主要因肠间质细胞的过度增殖及细胞外基质(extracellular matrix,ECM)的异常沉积所致,转化生长因子(transforming growth factor-beta,TGF-β)在此过程中起了关键作用.结缔组织生长因子(connective tissue growth factor,CTGF)作为TGF-β致纤维化作用的特异性下游介质,TGF-β的促肠纤维化作用可通过多种信号途径诱导CTGF的表达来完成,本文根据国内外研究资料,就肠纤维化的形成机制及TGF-β/CTGF在此进程中的作用和调控机制作一简要综述.Intestinal fibrosis is a serious complication of many inflammatory bowel diseases and is mainly caused by excessive proliferation of intestinal mesenchymal cells and abnormal deposition of extracellular matrix （ECM）. Transforming growth factor beta （TGF-β） plays a key role in the development of intestinal fibrosis~ Connective tissue growth factor（CTGF） is the specific downstream mediator in many of the important fibroproliferative effects of TGFβ. TGF-β-induced CTGF expression is mediated through several signaling pathways. This paper reviewed the current knowledge about the formation mechanism of intestinal fibrosis and discussed roles of TGF-βCTGF in this progression.

关 键 词：肠纤维化 转化生长因子-Β 结缔组织生长因子 信号转导 

分 类 号：R574[医药卫生—消化系统]