番茄红素对小鼠肝纤维化的治疗作用研究  

Therapeutic Effect of Lycopene on Hepatic Fibrosis in KM Mice

作　　者：张炜[1] 范钰[1] 朱丽群[1] 姚广涛[2] 李仪奎[2] 

机构地区：[1]江苏大学附属医院,江苏镇江212001 [2]上海中医药大学科技实验中心,上海201203

出　　处：《时珍国医国药》2008年第7期1743-1744,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的研究番茄红素对腹腔注射Con A诱导昆明鼠肝纤维化的治疗作用。方法70只昆明鼠随机分组:正常对照组10只,PBS腹腔注射、生理盐水灌胃,第9周处死这组小鼠;番茄红素治疗组50只,Con A腹腔注射8周,第9周起番茄红素灌胃,于第1,2,3,4,5次灌胃后1周各处死10只;安慰剂治疗组10只第9周起生理盐水灌胃,第14周处死。小鼠处死后测血清ALT,AST,肝组织病理检查。结果正常对照组未出现肝纤维化;安慰剂治疗组有典型肝纤维化;治疗组治疗5周后肝纤维化消失。结论番茄红素对肝纤维化有治疗作用。Objective To study the therapeutic effect of lycopene on hepatic fibrosis in KM mice induced by repeatedly administered concanavalin A. Methods 70 KM mice were divided into different groups. Control group, 10 mice, was injected- intraperitoneally weekly with PBS and intragastric administrated with 0.9% NS. Mice in this group were killed in the 9th week. Liver pathological changes were observed. Lycopene treatment group , 50mice, was intragastric administrated with lycopene after 9th week and then were killed in batch in 1,2,3,4,5 weeks later. Placebo group , 10 mice, intragastric administrated with 9% NS instead. ALT, AST in serum were measured. Liver pathological changes were also observed. Results Pathological examination showed that mice in control group did not catch hepatic fibrosis, mice in placebo group catch hepatic fibrosis, mice in treatment group were cured after 5 weeks. Conclusion Lycopene has a therapeutic effect on hepatitis fibrosis.

关 键 词：刀豆蛋白A 肝纤维化 动物模型 番茄红素 

分 类 号：R962[医药卫生—药理学]