紫杉醇联合顺铂双周和三周疗法治疗晚期非小细胞肺癌  

Double and Three-week Regime of Paclitaxel Combined with Cisplatin in Treatment of Advanced Non-small Cell Lung Cancer

作　　者：赵文艳[1] 邵欢[1] 钟皎[1] 曹洪富[1] 王丽萍[1] 缪建华[1] 

机构地区：[1]江苏无锡市第二人民医院药剂科,214002

出　　处：《肿瘤防治研究》2008年第7期518-520,共3页Cancer Research on Prevention and Treatment

基　　金：江苏省卫生厅奥赛康临床药学研究基金资助项目(P200505)

摘　　要：目的比较和评价紫杉醇联合顺铂双周和三周方案治疗晚期非小细胞肺癌(NSCLC)的近期疗效和毒性。方法经病理和细胞学证实的60例ⅢⅣ期NSCLC患者随机分为两组。双周疗法组(n=30例)紫杉醇80mg/m2,顺铂40mg/m2ivgttd1,8,第21天重复;三周疗法(n=30例)紫杉醇140mg/m2,顺铂60mg/m2ivgttd1,第21天重复。测定给药后3,12,24h的血药浓度,并评价经化疗2周期后的疗效和毒副反应。结果双周疗法和三周疗法的有效率分别为40.0%和33.3%,差异无统计学意义,但双周疗法的毒副反应发生率较低。结论紫杉醇联合顺铂双周方案治疗晚期NSCLC较三周疗法更为安全有效,患者易于接受,适用于临床,值得增加病例数做深入研究。Objective To evaluate the efficacy and toxicity of paclitaxel combined with cisplatin in the treatment of advanced non-small cell lung cancer （NSCLC） by double and three-week regime. Methods Sixty patients with locally advanced （ stage Ⅲ ） or metastatic （ stage Ⅳ ） NSCLC were enrolled into the study and divided to two groups. Double week regime（n = 30） ： paclitaxel 80 mg/m^2, cisplatin 40 mg/m^2 ivgtt d1,8,and it was repeated at d 21. Three-week regime （n = 30） ： paclitaxel 140 mg/m^2, cisplatin 60 mg/m^2 ivgtt dl and it was repeated at d 21. A HPLC method was established for the determination of paclitaxel at 3,12, 24 h after administration, and evaluate the efficacy and toxicity after two chemotherapy cycles. Results The overall response rate of double week regime and three-week regime were 40. 0% and 36. 7%, respectively, there was no statistic difference, but the main toxicities of double week regime were lower. Conclusion Double week regime is a better method for the treatment of advanced NSCLC, it could increase patients for further study.

关 键 词：非小细胞肺癌 紫杉醇 顺铂 双周疗法 三周疗法 

分 类 号：R730.53[医药卫生—肿瘤] R734.2[医药卫生—临床医学]