银屑病的免疫遗传学进展  

Immunogeneties of psoriasis

作　　者：郑文军[1] 林有坤[1] 

机构地区：[1]广西医科大学第一附属医院皮肤性病科,南宁530021

出　　处：《国际皮肤性病学杂志》2008年第4期243-245,共3页International Journal of Dermatology and Venereology

基　　金：广西科学基金资助（桂科自0342009-5）

摘　　要：临床资料和遗传流行病学调查发现，银屑病存在一定的遗传学背景。通过全基因组扫描和连锁分析，目前已在不同的染色体上筛查出19个以上潜在的银屑病易感基因位点，其中一些可在不同人群中得到重现，特别是与免疫相关基因的关系较为密切。目前多认为，该病的发生发展是遗传学因素、免疫学因素和环境因素共同作用的结果。Clinical and genetic epidemiological data have revealed a genetic background of psoriasis, With whole genome scanning and linkage analysis, more than 19 potential susceptible loci of psoriasis have been mapped to different chromosomes. Some of these sensitive genes are present in different populations and closely associated with immune gene. It is hypothesized that the development of psoriasis is a resultant of multiple factors including genetic bases, immune abnormality and environmental factors.

关 键 词：银屑病 免疫学 遗传学 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]