术前区域动脉灌注化疗治疗进展期低位直肠癌的临床研究  

Preoperative intra-arterial chemotherapy for progressive lower rectal cancer

作　　者：唐云强[1] 谭志明[2] 王嘉康[1] 汤日杰[2] 王俊[2] 赵宏宇[1] 麦聪[1] 张相良[1] 崔书中[1] 

机构地区：[1]广州医学院附属肿瘤医院腹外二科,广东广州510095 [2]广州医学院附属肿瘤医院放射科,广东广州510095

出　　处：《南方医科大学学报》2008年第7期1247-1248,1253,共3页Journal of Southern Medical University

基　　金：广州市卫生医药科技项目(2005-YB-107)~~

摘　　要：目的评价术前区域动脉灌注化疗在进展期低位直肠癌的临床疗效。方法45例进展期低位直肠癌分A和B两组,A组23例行术前区域动脉灌注化疗(PRAC),1-2周后行手术切除,B组22例单纯接受手术治疗。结果PRAC能够明显改变直肠癌的病理组织形态,总有效率95.65%。A组与B组的根治性切除率分别为91.3%和72.27%;术后1、3年生存率分别为95.65%和86.36%、86.96%和68.18%;术后3年复发率分别为8.69%和27.27%;低位直肠癌的保肛率分别为78.26%和59.09%。结论PRAC能提高进展期低位直肠癌的根治性切除率及生存率,减少术后复发率,提高低位直肠癌的保肛率。Objective To evaluate the therapeutic effect of preoperative regional intra-arterial chemotherapy （PRAC） on progressive lower rectal cancer. Methods Forty-five patients with progressive lower rectal cancer were divided into groups A （23 cases） and B （22 cases） for treatment with PRAC l to 2 weeks prior to surgical tumor resection or with surgical resection only, respectively. Results PRAC caused obvious tissue degeneration and necrosis of rectal cancer with a total effective rate of 95.65%. The rates of radical resection in groups A and B were 91.3% and 72.27%, respectively. The l-year postoperative survival rates of the two groups were 95.65% and 86.36%, with 3-year survival of 89.96% and 68.18%, and 3-year postoperative recurrence rates of 8.69% and 27.27%, respectively. The anal preservation rates of the two groups were 78.26% and 59.09%. Conclusion PRAC can increase radical resection rates, promote the postoperative survival and anal preservation rate, and lower the recurrence rate in patients with lower rectal cancer.

关 键 词：直肠肿瘤 术前区域动脉化疗 保肛手术 

分 类 号：R735.37[医药卫生—肿瘤]