水通道蛋白4与视神经脊髓炎  

Aquaporin-4 and Neuromyelitis Optica

作　　者：肖琴华[1] 涂江龙[1] 熊友生[1] 

机构地区：[1]南昌大学第二附属医院神经内科,330006

出　　处：《中国临床神经科学》2008年第4期433-436,共4页Chinese Journal of Clinical Neurosciences

摘　　要：水通道蛋白4(AQP4)是具有高度选择性的水通道特异蛋白,参与脑脊液的重吸收和渗透压调节。目前研究发现AQP4还参与视神经脊髓炎(NMO)的体液免疫机制,揭示了NMO是一种自身免疫性通道病,这一发现使NMO的免疫和病理学研究进入了一个新的阶段。AQP4作为NMO自身免疫反应攻击的靶点,为NMO的诊断和治疗开启一个新的领域。Aquaporin-4 was a highly preferential water channel protein, participating in the reabsorption of the cerebrospinal fluid and the osmoregulation, Investigation showed aquaporin-4 played an important role in humoral-mediated immunologic mechanism of neuromyelitis optica （NMO）. Meanwhile, NMO revealed an autoimmune channel disease, and the study on the immunopathogenesis of NMO was ushered into a new stage. AQP4 would be a new research field for the diagnosis and therapy of NMO.

关 键 词：水通道蛋白4 视神经脊髓炎 脑水肿 

分 类 号：R744.53[医药卫生—神经病学与精神病学]