褪黑素对自身免疫性肝炎肝组织病变的影响  

The effect of melatonin on hepatic tissue of autoimmune hepatitis

作　　者：马勇 丁体龙 袁福华 夏志学 

机构地区：[1]解放军第一二三医院南京军区肝病中心,安徽省蚌埠233015

出　　处：《中国基层医药》2008年第5期713-715,881,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的研究褪黑素（MT）对自身免疫性肝炎（AIH）肝组织病变的影响。方法制作大鼠自身免疫性肝炎模型，并随机分为模型对照组、MT注射组和猪促肝细胞生长素（pHGF）注射组。60d后，处死动物．取出肝脏，采用免疫组织化学法检测血管内皮生长因子（VEGF）的表达。结果MT组与模型对照组比较，肝组织炎症明显减轻，弹力纤维积分[（0．97±0．16）与（1．55±0．18）]、网状纤维积分[（1．09±0．17）与（2．00±0．14）]、胶原纤维增生积分[（1．31±0．17）与（3．00±0．14）]均降低（均P〈0．01），VEGF表达明显减弱。MT组与pHGF组无明显差异。结论褪黑素能明显改善自身免疫性肝炎大鼠模型肝组织病变。Objective To study the effects of melatonin（MT） on hepatic tissue of autolmmunc hepatitis （AIH）. Methods AIH model rats were divided randomly as model group, MT group and pig hepacyte growth factor （pHGF） group,to observe the pathological changes of hepatic tissue of the three groups. Results Hepatic tissue in- flammation and accrementition graded of elastic fibers, reticular fibre, collagenous fibrils of MT group [ （0.97 ± 0.16 ）, （ 1.09 ± 0.17 ）, （ 1.31 ± 0.17 ） ] were much lighter than model group [ （ 1.55 -± 0.18 ）, （2.00 ± 0.14 ）, （3.00 ± 0.14）] （all P〈 0.01 ）. The expression of VEGF was weaker in MT group than in pHGF group. There was no distinct difference between MT group and pHGF group. Conclusion MT can obviously improve the pathological changes of hepatic tissue of rats with AIH.

关 键 词：褪黑素 肝炎 自身免疫性 弹力纤维 纤维胶原类 血管内皮生长因子类 

分 类 号：R575[医药卫生—消化系统]