血清CYFRA21-1、NSE联合检测对肺癌诊断的临床意义  

Clinical significance of serum levels of the CYFRA21-1,NSE in the diagnosis of lung cancer

作　　者：李兴华[1] 付艳[2] 赵云芳[3] 

机构地区：[1]新疆医科大学第二附属医院检验科,新疆乌鲁木齐830028 [2]新疆医科大学第一附属医院门诊部,830054 [3]新疆医科大学第二附属医院输血科,830028

出　　处：《中国实验诊断学》2008年第7期888-889,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清CYFRA21-1与NSE联合检测对肺癌的诊断价值。方法应用电化学发光免疫分析技术测定77例肺癌患者、22例肺部良性疾病患者和120例健康对照组血清CYFRA21-1、NSE的水平。结果肺癌患者血清CYFRA21-1、NSE水平明显高于肺部良性疾病组和健康对照组(P<0.01)。CYFRA21-1在肺鳞癌中表达水平最高,NSE在肺小细胞癌中表达水平最高。血清CYFRA21-1+NSE联合检测肺癌的敏感性为68.8%,特异性为86.6%,准确性为80.4%。结论检测血清CYFRA21-1与NSE对肺癌诊断具有重要的临床参考价值,联合检测CYFRA21-1+NSE可提高肺癌检测的敏感性和准确性,并为肺癌的早期诊断、疗效监测、预后判断提供依据。Objective To study the clinical diagnostic value for lung cancer by combining test of the serum levels of CYFRA21- 1 and NSE. Methods CYFRA21-1 and NSE in serum samples of 77 patients with lung cancer, 22 cases with benign lung disease and 120 healthy people were determined by electro-chemiluminescence immunoassay. Results The levels of CYFRA21-1 and NSE in lung cancer group were significantly higher than those in group with benign lung disease and healthy people （ P 〈 0.01 ）. Patients with squamous cell carcinoma of lung had highest CYFRA21-1 level,patients with small ceil lung carcinoma had highest NSE level,when combining detection of the two tumormarkers were used for the diagnosis of lung canaer, sensitivity, specificity and accuracy were 68. 8 %, 86.6 % and 80.4 % respectively. Conclusion These results suggest that the serum CYFRA21-1 and NSE are of clinical importance for the diagnosis of lung cancer. Combination of CYFRA21-1 and NSE can improve the diagnostic sensitivity and accuracy, especially in providing evidence for lung cancer in the early diagnosis and improving the therapeutic effect and prognosis.

关 键 词：肺癌 CYFRA21—1 NSE 

分 类 号：R734.2[医药卫生—肿瘤]