大鼠母体孕期高脂高糖饮食对子代成年期动脉粥样硬化的影响  

Impact of maternal high fat and high calorie diet on AS of the offspring in rats

作　　者：肖婵云[1] 邹丽[1] 康玮[1] 周燕[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,430022

出　　处：《中国优生与遗传杂志》2008年第8期66-67,55,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的观察大鼠母体孕期高脂高糖饮食对子代成年期动脉粥样硬化的影响。方法20只雌性大鼠分成普食组(P组)和高脂高糖组(G组),孕期分别喂养两种饲料,G组子代雄性鼠分为高脂高糖组(G-G组)和普通饲料组(G-P组),P组子代雄性鼠仍普通饲料喂养(P-P组),子代大鼠12周末检测其血清氧化型低密度脂蛋白(OX-LDL),总甘油三脂(TG),总胆固醇(TC),高密度脂蛋白-C(HDL-C)及低密度脂蛋白-C(LDL-C)的浓度,同时利用HE染色切片观察子代成年大鼠主动脉的脂质沉积情况。结果①成年子代血清OX-LDL,TC和LDL-C浓度:在子代高营养组(P-G,G-G组)较子代普食组(P-P组)明显增高(P<0.01);在母亲高营养子代高营养组(G-G)较母亲高营养子代普食组(G-P)明显增高(P<0.05)。②血清TG和HDL-C浓度在各组无显著差异性(P<0.05。③母体孕期高营养的子代主动脉脂纹发生率在G-G组最高,G-P组次之,P-P组最低。结论母体孕期高营养饮食对子代成年期动脉粥样硬化有着重要的影响,子代在生长过程中普通饮食有利于延缓或防止动脉粥样硬化的发生。Objective： To observe the impact of maternal high fat and high calorie diet on AS of the offspring in rats. Methods. 20femal rats were grouped two groups, high nutrition group （G） and common diet group （P）, Pregnant rats were fed with high fat and high calorie diet and common diet respectively duration of pregnancy. The male offspring of G group were divided into two groups, high nutrition group （ G - G） and common diet group （ G - P）, and the male offspring of P group were still feed common diet, Then the Oxidation - low density lipoprotein （ OX - LD）, Triglyceride （ TG）, Total Cholesterol （ TC）, High density lipoprotein - cholesterol （HDL- C） and Low density lipoprotein- cholesterol （LDL- C） concentrations in serum were measured and observing the lipoid deposited in aortas which were dyed by HE at the end of 12 weeks. Results： ①The OX - LDL, TC and LDL - C concentration ： the G - P and G - G groups are significantly higher than the concentration of P - P group （ P 〈0. 01 ） ; The G - G group is higher than the G - P group （ P 〈 0. 05 ）.② The concentrations of TG and HDL - C are no difference in all groups （ P 〈 0.05）. ③The rate of offspring aortas fatty streak appearances in G - G group is the highest , and G - P group is the second, and the P - P group is the lowest. Conclusions ： Maternal high nutrition has great impact on AS of the offspring, and the offspring common diet can delay or prevent the occurrence of AS.

关 键 词：营养 胎源性 OX—LDL 血脂 动脉粥样硬化 

分 类 号：R715[医药卫生—妇产科学]