正常人三种运动任务的血氧水平依赖性磁共振脑功能成像定量分析  

BOLD-fMRI quantitive analysis of motor cortex by three hand motor tasks in normal subjects

作　　者：周福玲[1] 元小冬[1] 赵丽君[2] 王守红[2] 

机构地区：[1]河北省开滦(集团)有限责任公司医院神经内科,河北省唐山市063000 [2]河北省开滦(集团)有限责任公司核磁共振室,河北省唐山市063000

出　　处：《中国综合临床》2008年第8期798-801,共4页Clinical Medicine of China

摘　　要：目的利用全脑血氧水平依赖性磁共振脑功能成像（BOLD-fMRI）技术，探讨参与对指、握拳、被动运动的关键脑功能区。方法对10例健康右利手志愿者右手（利手）或左手（非利手）的对指、握拳、被动运动进行全脑BOLD-fMRI扫描，记录激活体积、激活强度，应用配对t检验进行定量分析。结果三种运动模式下，左手运动激活对侧感觉运动皮层（SMC）体积、强度大于右手运动（P〈0．05）。被动、对指运动激活对侧SMC体积、强度差异无统计学意义（P〉0．05）。被动、对指运动激活对侧SMC体积大于握拳运动（P〈0．05）。被动运动激活对侧SMC强度大于握拳运动（P〈0．05）。对指与握拳运动激活对侧SMC强度差异无统计学意义（P〉0．05）。结论脑功能区的激活情况与手运动复杂程度有关，体积、强度等定量指标进一步证实利手、非利手激活脑功能区的不对称性。恒定的被动运动（五指依次被动曲伸）任务用于BOLD-fMRI研究具有实用性、可靠性。Objective To identify the neural substrates of three motor tasks（repetitive and sequential finger-to-thumb opposition movements in turn, making fates, fingers passive flexion-extension movements in turn） of dominant and subdominant hands by using the whole-brain functional magnetic resonance imaging, Methods Ten right-handed healthy volunteers were scanned while they were performing the movement tasks with their right and left fingers. The motor cortex active volume and intensity was recorded . Quantitive analysis of motor cortex was conducted with paired t test. Results Under the three hand motor tasks, activation volumes in SMC during movements of the subdominant hand were significantly larger than those during movements of the dominant hand （ P 〈 0.05 ）. Acti- vation volumes during finger-to-thumb opposition movements and passive bending-extending fingers movements were significantly larger than those during movements of making fasts （ P 〈 0.05 ）. Activation intensity during passive bending-extending fingers movements was significantly larger than those during movements of making fasts （ P 〈 0.05 ）. Conclusion The representation of the Motor Cortex is related to the complexity of the hand motor exercises. Quan- titive criterion as volume and intensity approves the dissymmetry of cortex activation by dominant and subdominant fingers＇movements. It is practicable and credible to adopt invariable fingers passive flexion-extension movements in turn in the study on BOLD-fMRI.

关 键 词：磁共振脑功能成像 手运动 

分 类 号：R445.2[医药卫生—影像医学与核医学]