谷胺酰胺颗粒灌肠对溃疡性结肠炎患者IFN-γ、IL-4、IL-8的影响及疗效观察  

Effects of Coloclysis with Glutamine Granule on IFN-γ,IL-4 and IL-8 Levels and Therapeutic Effect in Patients of Ulcerative Colitis

作　　者：张文礼[1] 

机构地区：[1]四川省宜宾市一医院消化内科,四川宜宾644000

出　　处：《医学临床研究》2008年第7期1265-1267,共3页Journal of Clinical Research

摘　　要：【目的】观察谷胺酰胺颗粒灌肠对溃疡性结肠炎(UC)患者IFN-γ、IL-4、IL-8的影响及疗效。【方法】96例慢性UC患者随机分为治疗组与对照组。治疗组患者用谷胺酰胺颗粒,2.5 g加入生理盐水100mL温生理盐水混匀灌入肠内保留,每晚一次;左氧氟沙星0.3 g(100 mL)加入地塞米松5 mg,晨起1次,排便后保留灌肠,15 d为一个疗程。对照组患者仅给予左氧氟沙星0.3 g(100 mL)加入地塞米松5 mg保留灌肠,每日2次。观察治疗前后IFN-γ、IL-4、IL-8水平的变化,血液指标WBC、PLT、血沉(ESR)、C反应蛋白(CRP)改变,临床治疗总有效率。【结果】两组治疗后IFN-γ、IL-8水平明显较治疗前降低,IL-4水平明显增高(P<0.01)。治疗组治疗后IFN-γ、IL-8水平低于对照组,IL-4水平则高于对照组(P<0.05);两组患者血液指标WBC、PLT、ESR及CRP均较治疗前明显降低(P<0.05),治疗组临床总有效率优于对照组,治疗组在治疗后发生腹痛和黏液血便的人数明显少于对照组(P<0.05)。【结论】谷胺酰胺颗粒、左氧氟沙星联合地塞米松保留灌肠治疗UC可调节体内细胞因子水平,收到较好的临床疗效。[Objective]To investigate the effects of coloclysis with glutamine granule on interferon gamma （IFN-γ）, interleukin-4（IL-4） and interleukin-8（IL-8） levels and therapeutic effect in patients of ulcerative colitis. [Methods]A total of 96 patients suffered ulcerative colitis were divided randomly into two groups., treatment group and control group. In the treatment group, 48 patients were treated by coloclys/s with 2.5g glutamine granule dissolved in 100ml warm normal sodium once a night, then at second morning patients were treated by coloclysis with levofloxacin （0.3g, 100mL）plus 5mg dexamethasone after defecation. In the control group, all patients were only treated by coloclysis with levofloxacin （0.3g, 100mL） plus 5rag dexamethasone after defecation twice per day. IFN-γ, IL-4 and IL- 8 level, white blood cell （WBC）, platelet （PLT）, erthyrocyte sedimentation rate （ESR） and C-reactive protein （CRP） were measured before and after treatment. The therapeutic effect was evaluated by coloscope and clinical signs. [Results] After treatment, IFN-γ, IL-4 and IL-8 levels in two groups were both improved significantly（ P 〈 0. 01）. In the treatment group, IFN-γ, IL-4 and IL-8 levels were improved significantly as compared with the control Group（ P 〈0.05）. WBC, PLT, ESR and CRP were decreased significantly after treatment（ P 〈0.01）. Total effective rate of the treatment group was higher than that of control group（ P 〈0. 05）. The incidence of abdominal pain and mucus-bloody stools in the treatment group was decreased significantly as compared with that of control group [Conclusion] Coloclysis with glutamine granule is an effective treatment for patients suffered ulcerative colitis through the regulation of cytokine levels.

关 键 词：结肠炎 溃疡性/药物疗法 干扰素Ⅱ型 白细胞介素4 白细胞介素8 

分 类 号：R574.62[医药卫生—消化系统]