多器官功能障碍综合征发病机制的研究进展  

Research Advancement in Pathogenic Mechanism of Multiple Organ Dysfunction Syndrome

作　　者：武瑞清[1] 

机构地区：[1]天津市儿童医院普通外科,天津300074

出　　处：《医学综述》2008年第15期2249-2252,共4页Medical Recapitulate

摘　　要：多器官功能障碍综合征病死率较高,充分认识其发病机制有助于提高对该病的预防和诊治,降低病死率。由于其发病机制较为复杂,目前尚无统一说法。随着近年来分子生物学和基因医学的发展,人们对其发病机制有了进一步了解。本文对该病与全身炎性反应综合征的关系,多种细胞因子与炎性介质的作用以及各种发病假说的研究进展予以综述。Multiple Organ Dysfunction Syndrome （MODS） has high mortality, and it is helptul in improvement of its diagnosis, treatment and prognosis to know its pathogenic mechanism, as well as in decreases of mortality. Due to complexity, the pathogenic mechanism of MODS is still in dispute. With the development of molecular biology and gene medicine in recent years, there has made progress in this syndrome. This article reviewed the relationship between MODS and systemic inflammatory response syndrome （ SIRS）, different cytokines and their effects,and different hypothesis of MODS.

关 键 词：多器官功能障碍综合征 全身炎性反应综合征 细胞因子 

分 类 号：R363.21[医药卫生—病理学]