住院抑郁症患者血清同型半胱氨酸水平研究  

The levels of serum homocysteine in the inpatients with major depressive disorder

作　　者：王善信[1] 李浩福 王斌[1] 殷爱华[1] 王旸[1] 

机构地区：[1]山东省精神卫生中心,济南250014 [2]山东省寿光市精神卫生中心

出　　处：《精神医学杂志》2008年第4期275-277,共3页Journal of Psychiatry

摘　　要：目的探讨抑郁症患者血清同型半胱氨酸水平与抑郁症发病的相关性。方法将40例抑郁症患者作为研究组,选取36名心身健康正常人为对照组,应用荧光偏振免疫法检测血清同型半胱氨酸水平。结果研究组患者血清同型半胱氨酸水平与性别、药物治疗、家族史、年龄、病程均无相关性(P>0.05)。研究组患者血清同型半胱氨酸水平显著高于对照组[(16.45±5.96)μmol/L,(11.72±3.33)μmol/L;P<0.05],研究组患者高同型半胱氨酸血症发生率显著高于对照组[(42.50)%,(10.00)%,P<0.05]。研究组中,汉米尔顿抑郁量表评分与血清同型半胱氨酸水平呈显著正相关(r=0.724,P<0.05),高同型半胱氨酸血症患者的汉米尔顿抑郁量表评分显著高于无高同型半胱氨酸血症患者(t=5.209,P<0.05)。结论血清同型半胱氨酸水平升高可能是抑郁症发病的重要危险因素之一,血清同型半胱氨酸水平对抑郁症严重程度有一定影响。Objective To investigate serum levels of homocysteine in inpatients with major depressive disorder and relationship between serum homocysteine levels and depressive symptoms. Methods A total of 40 patients with major depressive disorder in study group and 36 normal health controls in control group were collected in this study. The serum levels of homocysteine were determined by Fluorescence Polarization Immunoassay （FPIA）. The 17-item Hamilton Rating Scale for Depression （HAMD） was used to evaluate depressive symptoms. Results In study group, the serum homocysteine level was not significantly related to sex, treatment, family history, age and duration of depression（P〈0.05）. The serum homocysteine level was significantly higher in study group than that in control group[（16.45±5.96）μmol/L,（11.72±3.33）μmol/L;P〈0.05]. The rate of Hyperhomocysteinemia （HHcy） in study group was significantly higher than that in control group [（42.50）%, （10.00）% ,P〈0.05]. In study group, the score of HAMD was significantly positively related to serum homocysteine level（ r=0. 724, P〈0.05 ）. The score of HAMD in patients with HHcy was significantly higher than that in patients without HHcy （ t=5. 209, P〈0.05 ）. Conclusion The increase of serum homocysteine levels maybe play an important risk factor in the pathogenic mechanism of depressive disorder,and the serum homocysteine level could influence severity of depression.

关 键 词：抑郁症 同型半胱氨酸 

分 类 号：R749.4[医药卫生—神经病学与精神病学]