蒙医灸疗对功能性消化不良模型大鼠胃排空和血浆胃动素、血清促胃液素的影响  

THE EFFECT OF MONGOLIAN MOXIBUSTION THERAPY ON GASTRIC EMPTYING AND PLASMA MTL AND SERUM GAS IN FD RATS

作　　者：乌云格日乐[1] 斯钦图 

机构地区：[1]内蒙古医学院蒙医药学院,内蒙古呼和浩特010059

出　　处：《内蒙古医学院学报》2008年第3期195-198,共4页Acta Academiae Medicinae Neimongol

基　　金：国家自然基金项目(30760323)

摘　　要：目的:本研究以"胃穴"、"火降穴"为切入点,以胃排空率和血清促胃液素(GAS)、血浆胃动素(MTL)为指标,观察了蒙医灸疗对功能性消化不良(FD)模型大鼠的影响,同时探讨灸疗法防治FD的作用机理。方法:将28只清洁级健康Wistar大鼠按体重随机分为空白对照组、模型对照组和灸疗组;模型对照组和灸疗组大鼠采用夹尾激怒法制造FD模型大鼠,实验第7d造模成功后,灸疗组大鼠给予施灸因素,模型对照组大鼠给予与灸疗组大鼠同样抓取固定因素;采用分光光度法和放免法测定胃排空率和血清GAS、血浆MTL值。结果:治疗后,灸疗组大鼠胃残留率与模型组比较有显著差异(P<0.05),GAS有显著差异(P<0.05)、血浆MTL无显著差异(P>0.05)。结论:①蒙医灸疗"胃穴"、"火降穴"对FD模型大鼠有促进胃排空作用;②蒙医灸疗"胃穴"、"火降穴"对FD模型大鼠血清GAS有提高作用,对血浆MTL的作用不显著;③胃穴可能是通过"隐居白脉"来提高FD模型大鼠GAS;火降穴可能是通过近端穴位热效应来促进FD模型大鼠胃排空。④本研究对灸疗法作用机理、组穴原理、组穴配伍规律等研究提供可靠理论依据和方法学依据。By giving moxibustion to＂ stomach moxibustion point＂ and ＂Huojiang moxibustion point＂ of rats model with functional dyspepsia （ FD）, to observe the effect of Mongolian moxibustion therapy on the gastric emptying and gastrointestinal hormone of FD rats. Methods：28 healthy and clean Wistar rats were randomly divided into three groups （ control group, model group, moxibustion group ）. FD rats model was made through irritating the rats by clamping their tails. In seven days modeling succeed, the moxibustion group received moxibustion therapy, the model group received the factor of fix and grab, same as the moxibustion group. The gastric emptying rate, GAS and MTL in the blood were detected by the method of pouring methyl orange into stomach and radioimmunoassay. Resuits：After treatment, the residual rate of stomach in moxibustion group has significant difference with the model group＇ s （ P 〈 0. 01 ）. Serum GAS of two groups has significant difference （P 〈 0. 05 ）. There was no significant difference in plasma MTL of two groups （ P 〉 0. 05 ）. Conclusion ： 1. Mongolian moxibustion on ＂stomach moxibustion point＂ and ＂Huojiang moxibustion point＂ have the function of promoting gastric emptying in treating with FD rats. 2. Mongolian moxibustion on＂ stomach moxibustion point＂ and ＂Huojiang moxibustion point＂ have the function of raising the level of serum GAS, but the function of raising the level of plasma MTL was indistinctive. 3. ＂ Stomach moxibustion point＂ have the function of improving GAS by＂seclusive white -vein＂ in treating with FD rats. And ＂Huojiang moxibustion point＂ have the function of promoting gastric emptying by adjacent point＇ s thermal effect. 4. The study offers reliable theory and methodological basis to the effect of moxibustion therapy, principle of group points and compatibility of group points.

关 键 词：蒙医灸疗法 功能性消化不良 胃排空 胃肠道激素 实验研究 

分 类 号：R776.4[医药卫生—眼科]