神经退行性或损伤性疾病防治的新视点——干细胞药物  

A new insight and strategy of treatment and prevention for neurodegenerated or damaged disease-stem cell drugs

作　　者：韩梅[1] 张文生[2] 李金凤[1] 孙媛媛[1] 朱友惠[1] 王永炎[2] 

机构地区：[1]北京师范大学化学学院.放射性药物教育部重点实验室,北京100088 [2]北京师范大学资源学院,北京100088

出　　处：《中国药理学通报》2008年第7期841-844,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30672491);国家重点基础研究发展计划(973计划)资助项目(No2003CB517105);北京市新医学科群资助项目(NoXK100270569)

摘　　要：干细胞药物是指可以通过调节生物体内干细胞的增殖与分化,来防治由于细胞缺失或损伤而引起疾病的一类治疗和预防药物。近年来发现:运用中药、生长因子和小分子化合物均可调节生物体内干细胞的增殖与分化;而神经系统退行性或损伤性疾病:包括帕金森病(PD)、阿尔采末病(AD)、亨廷顿病(HD)、药物滥用、抑郁症以及脑卒中等,均是由于神经细胞的缺失或损伤而引发的疾病。运用药物来调节自身神经干细胞的增殖与定向分化潜能,以重建受损的功能细胞,恢复其生物学功能,既解决了成体神经干细胞的来源困难和胚胎干细胞的伦理困惑问题,也避免了细胞移植的免疫排斥和手术后遗症问题。为细胞丢失或损伤性疾病的防治提供了崭新的视点和思路。Stem cell drugs can treat or protect the diseases due to functional ceils lost or damaged by regulating the proliferation and differentiation of internal stem cells. Recently, it has been found that a few Traditional Chinese Medicines, growth factors and small molecule compounds can improve the proliferation and differentiation of neural stem cells. Neurodegenerated diseases, such as Parkinsons disease, Alzheimers disease, Hentindons disease,as well as drug abuse, depression, ischemic stroke are all caused by neural functional cell loss or damage. Thus, inducing proliferation and differentiation of internal neural stem cells by drugs can rebuild the lost or damaged functional cells. Stem cell drugs not only resolve the limitation of adult neural stem cell resources and the ethic boundary of embryonic stem cells, but also avoid immune rejection and operational sequelae. The stem cell drugs provide a new insight and strategy of treatment and prevention for these kinds of diseases.

关 键 词：干细胞药物 中药 神经干细胞 调节干细胞的增殖与分化 神经退行性或损伤性疾病 

分 类 号：R-05[医药卫生] R322.81