涎腺多形性腺瘤微血管密度及血管内皮生长因子表达的意义  

Significance of microvessel density and vascular endothelial growth factor expression in pleomorphic adenoma of salivary glands

作　　者：杨文军[1] 刘应时[1] 陈巨峰 康博 张学斌 

机构地区：[1]广东佛山科学技术学院医学院,528000 [2]广东省佛山市第一医院口腔科 [3]佛山市口腔医院 [4]佛山市南海区妇儿医院口腔科

出　　处：《实用口腔医学杂志》2008年第4期571-574,共4页Journal of Practical Stomatology

基　　金：佛山市科技攻关计划项目(佛山市科技局项目2004-887)

摘　　要：目的:研究多形性腺瘤中血管内皮生长因子(VEGF)的表达和微血管密度(MVD),探讨其与该肿瘤的临床病理意义。方法:采用SP免疫组化染色方法检测33例多形性腺瘤中VEGF的表达和MVD,用SPSS统计软件进行分析。结果:VEGF在多形性腺瘤中的表达率明显高于正常涎腺(P<0.05);MVD在多形性腺瘤中的分布与正常涎腺组织无显著性差异(P>0.05);VEGF在多形性腺瘤中的表达与MVD无显著相关性。结论:在涎腺多形性腺瘤中,VEGF有较高水平表达,MVD的分布需进一步研究。Objective ：To examine microvessel density （MVD） and the expression of vascular endothelial growth factor （VEGF） in pleomorphic adenoma （PA） of salivary gland and to explore the relationship among the expression of VEGF, the MVD and the biological behavior of PA. Methods：MVD and the expressions of VEGF in 33 PA patients and control groups were detected by immunohistochemistry. The data was analyzed by SPSS software. Resuits ：The expression of VEGF in PA was higher than that in normal controls（ P 〈0. 05）. No significant difference was seen between the MVD in PA and that in controls（P 〉0.05 ）. No correlation was found between the expression of VEGF and MVD in PA. Conclusion： There is high level of VEGF expression in PA. Further research is required on the expression of MVD in PA.

关 键 词：腺瘤 多形性 涎腺 血管生长因子 微血管密度 

分 类 号：R739.8[医药卫生—肿瘤]