外阴上皮内瘤样病变  

Vulvar intraepithelial neoplasia

作　　者：黄勤[1] 王景美[1] 胡娅莉[2] 

机构地区：[1]南京大学医学院附属鼓楼医院病理科,江苏南京210008 [2]南京大学医学院附属鼓楼医院妇产科,江苏南京210008

出　　处：《医学研究生学报》2008年第2期199-202,共4页Journal of Medical Postgraduates

基　　金：南京市医学重点科技发展项目基金资助(批准号:ZKX05013)

摘　　要：外阴上皮内瘤样病变（VIN）是用来描述外阴皮肤鳞状上皮异常增生的一组癌前病变。近年来，其发病率快速上升。基于有无人乳头状瘤病毒（HPV）感染，VIN可分为HPV阳性及阴性两类。前者通常发病年龄较轻，31％～40％可能进展为浸润性癌；后者常与硬化性苔藓相关，发生于老年患者，约60％可能进展为浸润性癌。VIN根据形态学特征及病变深度，可分为Ⅰ级、Ⅱ级和Ⅲ级。VIN可自行消退，但也可能进展为浸润性癌。激素治疗可阻止其恶性转化，但不能达到治愈，外科手术切除是浸润性癌的主要治疗手段。Vulvar intraepithelial neoplasia （VIN） is a group of premalignant dysplastic squamous cell lesions, the incidence of which has rapidly increased recently. Based on the presence or absence of human papilloma virus （HPV） infection, VIN is currently divided into HPV-positive and -negative types. The former usually occurs in young women, with 31% -40% developing into invasive carcinoma, while the latter usually in older patients, frequently associated with lichen sclerosus and with 60% developing into invasive vulvar carcinoma. Histopathologically, VIN can be classified into Type Ⅰ, Ⅱ and Ⅲ according to morphological features. VIN can spontaneously regress as well as progress to invasive carcinoma. The current therapy with ultra-potent corticosteroid can protect the patients from malignant progression but can not cure VIN. Surgical resection is reserved only for invasive carcinoma.

关 键 词：外阴上皮内瘤样病变 人乳头状瘤病毒 鳞状细胞癌 

分 类 号：R737.35[医药卫生—肿瘤]