磷酸化蛋白质组学技术及其在肿瘤研究中的应用  

Phosphoproteomics and its application in cancer research

作　　者：刘洁琼[1] 贺智敏[1] 

机构地区：[1]中南大学肿瘤研究所,长沙410078

出　　处：《中南大学学报（医学版）》2008年第7期559-564,共6页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(30470688)~~

摘　　要：磷酸化蛋白质组是指机体细胞在特定时间和空间上表达的所有磷酸化蛋白质;磷酸化蛋白质组学是在整体水平上研究磷酸化蛋白质在细胞中的组成成分、表达水平、修饰状态及相互作用规律的学科。近年来,磷酸化蛋白质学技术已广泛应用于肿瘤研究,为阐明肿瘤的发生机制,提高肿瘤的诊治水平提供了重要信息。Phosphoproteome is the whole complement of phosphorylated proteins in a cell, tissue or organism, and has become an interesting study subject since the discovery of phosphorylation as a key regulatory mechanism of cell life. Phosphoproteomics is a method which studies the compact of the phosphorylated proteins, expression and modification, interaction and association, rule of the regulatory and so on. Recently, phosphoproteomics is widely used in cancer research. It will provide important information in cancer research, cancer diagnosis, and therapy.

关 键 词：磷酸化蛋白质组学技术 恶性肿瘤 诊断 治疗 

分 类 号：R73-3[医药卫生—肿瘤]