非小细胞肺癌化疗后应用白细胞介素-2、维甲酸的临床效果观察  

Effect of interleukin-2 and retinoic acid on patients with nonsmall cell lung cancer after chemotherapy

作　　者：张岚[1] 吴江[1] 王笑碧[1] 庞世权[1] 余海清[1] 

机构地区：[1]广东省深圳市宝安区人民医院肿瘤科,广东深圳518101

出　　处：《实用医院临床杂志》2008年第4期48-49,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨白细胞介素-2、维甲酸联合化疗治疗晚期非小细胞肺癌的近期疗效和不良反应。方法13例晚期非小细胞肺癌患者紫杉醇＋顺铂（TP）方案化疗后白细胞介素-2皮下注射20万单位,2天1次;顺式-维甲酸20 mg,每天3次口服,评价疗效及不良反应。结果完全缓解（CR）1例,部分缓解（PR）6例,稳定（NC）5例,进展（PD）1例,总有效率（RR）为54%,主要的不良反应为恶心、呕吐和骨髓抑制等,12例为Ⅰ-Ⅱ度不良反应,患者耐受良好。结论白细胞介素-2、维甲酸联合TP方案化疗是一种对晚期非小细胞肺癌有效的治疗方案,不良反应轻,值得临床进一步研究应用。Objective To evaluate the efficacy and toxicity of the combination of chemotherapy with interleukin-2 and retinoic acid for advanced non-small cell lung cancer （ NSCLC ）. Methods Thirteen NSCLC patients who had been treated by TP chemotherapy were subcutaneously injected 200 000 U interleukin-2 once per two days and 20 mg retinoic acid orally three times a day, The efficacy and side effects were assessed, Results Among the 13 patients, 1 achieved complete response, 6 achieved partial response, 5 non-response and 1 had progressive disease. The overall response rate was 54%, The major toxicities included nausea, vomiting and marrow suppression. The incidence rate of severe toxicities was generally low and all the side effects were mild （ grade Ⅰ - Ⅱ） and well tolerated. Conclusion The combination of TP chemotherapy with interleukin-2 and retinoic acid is effective in treating advanced non-small cell lung cancer, and the adverse reaction is mild.

关 键 词：非小细胞肺癌 化疗 白细胞介素-2 顺式-维甲酸 

分 类 号：R734.2[医药卫生—肿瘤]