纳洛酮冲击疗法超快速脱毒的临床研究  

Clinical study of fast detoxification therapy by the rapid and high does Naloxone

作　　者：王文甫[1] 单飞豹[1] 刘国阳[1] 蒋铁平[1] 陈辞珍[1] 陈碧英[1] 易仁忠[1] 

机构地区：[1]湖南省脑科医院自愿戒毒中心,长沙市410007

出　　处：《中国药物滥用防治杂志》2008年第4期189-192,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:纳洛酮冲击治疗,使海洛因依赖者住院三天内一次性完成脱毒治疗。方法:按纳曲酮冲击疗法,操作程序准备及用药,冲击治疗药物为纳洛酮,在冲击治疗期间及次日各静舒氧一次30例,为A组;冲击治疗药物为纳曲酮者30例,为B组,进行对照比较两组住院至冲击治疗时间,冲击治疗中反应及治疗后戒断症状,不良反应等。A组患者冲击治疗前后进行血常规、肝功能、肾功能及心电图检查。结果:A组患者平均住院2.4天完成脱毒,较B组(平均6.7天)明显提前(P<0.01)。A组冲击治疗期间也有P、R、BP、升高,但比较平稳。冲击治疗后戒断症状、不良反应较B组重,但均在可忍受范围。对肝功能、肾功能、心电图没有明显影响,冲击成功率100%。结论:纳洛酮冲击治疗安全可靠,可明显提前完成脱毒治疗,很有临床实用价值。Objective ：To study treat detoxification of heroin addicts in hospital patients 3 days by rapid and high does ofNaloxone （NLX） therapy .Methods： The method of rapid and higher does Naltrexone we added Jing Shu Yang for 2 days in 30 patients （A group）. The average from admission to treatment, the evaluation of withdrawal symptoms and side effects was carded everyday by special qualification, and its clinical analysis was compared with 30 cases in control, i.e. The rapid and higher does Nalthexone （B group）. Results： A group the average from admission to treatment 2.4 days was shorter than B group 6.7 days （P〈0.01）. A group the time of treatment P, R, BP was smoother than B group. After treatment withdrawal symptom and side effects was weighter than B group （P〈0.01）. But, it may bear. This therapy had no significant influence on the function of heart, liver and kidney. The cure rate of the therapy was 100%. Condusions： This therapy is efficient and safe. Patients in ahead of schedule complete the detoxification.

关 键 词：海洛因依赖 纳洛酮 冲击治疗 

分 类 号：R749.64[医药卫生—神经病学与精神病学]