(±)-HypoglycinA的全合成  

Total Synthesis of (±)-Hypoglycin A

作　　者：肖啸[1] 肖玉梅[1] 刘文剑[1] 王明安[1] 付滨[1] 李楠[1] 覃兆海[1] 孔凡伦 

机构地区：[1]中国农业大学理学院,北京100094 [2]河南省林业学校,河南洛阳471002

出　　处：《合成化学》2008年第4期402-405,共4页Chinese Journal of Synthetic Chemistry

摘　　要：采用Wittig试剂与环氧氯丙烷和多聚甲醛构建亚甲基环丙烷结构单元,利用2,5-二乙氧基-3,6-二氢吡嗪引入氨基酸结构单元,通过6步反应成功实现了天然植物毒素Hypoglycin A外消旋体的全合成,总收率3.2%。中间体和Hypoglycin A的结构经1H NMR表征。对反应中的问题进行了分析和讨论。（ ± ）-Hypoglycin A in total yield of 3.2% was synthesized by a six-step reaction, including the construction of methylenecyclopropane using Wittig reagent to react with epichlorohydrin andpolyaldehyde, and the introduction of α-amino acid moiety by 2,5-diethoxy-3,6-2H-pyrazine as the key step, The structurs of intermediate and （ ± ）-Hypoglycin A were confirmed by 1H NMR. The problems in the synthesizing process were also discussed.

关 键 词：Hypoglycin A 全合成 植物毒素 

分 类 号：O623.736[理学—有机化学]