原发性胃淋巴瘤临床病理因素与预后的关系  

Relationship between the prognosis and clinicopathological characteristics of gastric lymphoma

作　　者：段伦喜[1] 赵华[1] 冯大作[1] 刘国清[1] 李铁钢[1] 钟德王午 胡辅珍[1] 皮执民[1] 雷三林[1] 

机构地区：[1]中南大学湘雅二医院普通外科,湖南长沙410011

出　　处：《中国现代医学杂志》2008年第14期2055-2058,2061,共5页China Journal of Modern Medicine

摘　　要：目的分析原发性胃淋巴瘤预后与各临床病理因素及治疗的关系。方法随访该院33年间因原发性胃淋巴瘤接受手术治疗的病人,用Kaplan-Meier生存时间分析、COX多因素分析研究生存预后与各临床病理因素以及治疗的关系。结果整体3年存活率为85%,5年存活率为67.24%。手术+化疗3年存活率为86.35%,5年存活率为82.43%。细胞分级、周围器官或远处转移、手术方式、术后是否化疗是原发性胃淋巴瘤的独立预后因子,其他临床病理因素与原发性胃淋巴瘤预后尚无显著相关。结论胃淋巴瘤的治疗应以手术、化疗为主,化疗可能更为重要,联合应用可以获得较满意的效果。根据细胞分级、周围器官或远处转移、手术方式、术后是否化疗可以预测原发性胃淋巴瘤的预后。[Objective] To investigate the relationship between the elinieopathologieal characteristics and treatment and the prognosis of primary gastric lymphoma （PGL）. [Method] Following up the PGL patients received operative treatment in the past 33 years in our hospital, the influence of each elinieopathologieal factor and treatment on survival was assessed by Kaplan-Meier survival analysis and COX proportional hazard model. [Result] 3-years sur- vival rate was 85%, 5-years survival rate was 67.24%. Grade of tumor cell, metastasis, operative mode, chemotherapy were prognostic indicators for PGL, other elinieopathologieal factors weren＇t independent indicators. [Conclusion] Gastrectomy and chemotherapy may be the main therapeutic means for PGL, chemotherapy may be more important, gastreetomy combined chemotherapy can get good prognosis. Grade of tumor cell, metastasis, operative mode, chemotherapy can predicate the prognosis for primary gastric lymphoma.

关 键 词：原发性胃淋巴瘤 预后 临床病理因素 胃切除 

分 类 号：R735.2[医药卫生—肿瘤]