熊果酸抗肿瘤机制研究进展  

Progress of research on anti-cancer mechanism of ursolic acid

作　　者：海龙[1] 苏秀兰[1] 毕力夫[1] 

机构地区：[1]内蒙古医学院附属医院中心研究室,内蒙古呼和浩特010050

出　　处：《中华肿瘤防治杂志》2008年第11期870-872,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：内蒙古自治区自然科学基金(200711020906)

摘　　要：目的：总结国内外对熊果酸抗肿瘤机制的研究现状。方法：应用CNBI及中国期刊全文数据库检索系统，以“熊果酸、细胞凋亡、肿瘤”等为关键词，检索1979—01-01～2005-12—30相关熊果酸的文献。纳入标准：1）熊果酸对细胞周期影响的研究；2）熊果酸对凋亡相关基因Caspase蛋白表达影响的研究；3）熊果酸对凋亡相关基因Bcl-2／Bax、Fas／FasL和Survivin表达影响的研究。粗选有70余篇关于熊果酸方面的文章，根据纳入标准，精选42篇文献，最后纳入分析29篇文献。结果：熊果酸对结肠癌、黑色素瘤和胃癌等多种细胞系具有抑制作用，并诱导其凋亡。其机制可能是通过影响细胞周期及癌相关基因的表达而实现的。结论：熊果酸具有很好的抑制肿瘤生长作用，并且毒副反应小，来源丰富，有待开发。OBJECTIVE：To summarize the situation of the re- search about the antineoplastic mechanism of ursolic acid. METHODS： The retrieve system of CNBI and the data base of Chinese Periodicals was used to search documents about ursolic acid from 1979-01-01 to 2005-12-30, with ＂ursolic aid, cell withering, tumor＂ as the key words. Standards of getting in： 1）about the effect of ursolic acid on the mitotic cycle; 2）about the effect of ursolic acid on the protein expression of wethering related gene Caspase; 3） about the effect of ursolid acid on the expression of wethering related genes Bcl-2/Bax, Fas/FasL and Survivin. Seventy articles were generally select, and then according to the above standards, 42 of the articles were chosen. Based on the 42 articles, 29 were summarized for study. RESULTS： The ursolic acid could cause retarding effect on many cells such as colon cancer, melania cancer and stomac cancer. CONCLUSIONS： The ursolid acid has the function of retarding tumor growth with little poisonous side effect, and it has a rich source of supply. Therefore ursolic acid is expected to be developted.

关 键 词：熊果酸 肿瘤抑制蛋白质类 细胞周期蛋白质类 细胞凋亡易感蛋白 综述文献 

分 类 号：R730.5[医药卫生—肿瘤]