恶性肿瘤^(18)F-FDG PET延迟显像临床研究的进展  

Advances in clinical research of dual-time-point ^(18)F-FDG PET imaging in evaluation of malignant lesions

作　　者：胡漫[1] 杨文峰[2] 于金明[1] 

机构地区：[1]山东省肿瘤医院放疗科,山东济南250117 [2]山东省肿瘤医院胸外科,山东济南250117

出　　处：《中华肿瘤防治杂志》2008年第11期873-876,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：山东省医药卫生科研项目(2005HW137)

摘　　要：目的:总结18F-氟脱氧葡萄糖正电子发射断层显像(18F-FDG PET)延迟显像在恶性肿瘤中的临床研究进展。方法:以正电子发射断层显像、18F-氟脱氧葡萄糖、延迟显像和肿瘤为关键词,应用CHKD期刊中文数据库和PubMed英文数据库,检索1999年~2007年相关PET延迟显像的文献。共收集113篇关于FDG PET延迟显像方面的文章,选取28篇具有代表性的与本研究有关的文献进行分析。结果:FDG PET延迟显像和储留指数对肺癌、胰腺癌、鼻咽癌和宫颈癌等恶性肿瘤的诊断具有很高的灵敏度和特异性,SUV的变化有助于恶性肿瘤的分期、再分期和治疗方案的制定,是一种预测治疗反应性、生存期和放化疗后复发的理想方法。结论:FDG PET延迟显像能帮助我们提高对肿瘤本身及其周围环境生物学方面的认识,从而更好的应用于肿瘤的防治。OBJECTIVE： To summarize the dual-time-point ^18F-FDG PET imaging in evaluation of malignant lesions. METHODS： In this article, PET, FDG, dual-time-point imaging, tumor being the key words, we reviewed the articles published from the databases such as CHKD and PubMed, particularly from 1999 to 2007. We collected 113 articles together, after excluding the articles without relation of this study, we selected the representative focus literature 28 into analysis. RESULTS： Many reports indicated that the utility of dual-time-point imaging and the retention of ^18F-FDG were tested in patients with high sensitivity and specificity for pulmonary nodules, pancreatic cancer, nasopharyngeal carcinoma, cervical cancer and so on. SUV, both initially and over times （for difficult cases） could be useful for staging, restaging and the management of patients with malignant lesions, and also provide a good way to predict the response, survival, and recurrence after the radio-chemotherapy. CONCLUSION： Such studies may improve our knowledge about the change in tumor biology according to the ambient environment and act as a crucial tool to fight against cancer.

关 键 词：正电子发射断层显像 ^18F-氟脱氧葡萄糖 延迟显像 肿瘤 综述文献 

分 类 号：R730.4[医药卫生—肿瘤]