皮质下缺血性脑血管病白质改变与认知损害初探  

RELATIONSHIP OF WHITE MATTER CHANGES AND COGNITIVE IMPAIRMENT IN SUBCORTICAL ISCHEMIC VASCULAR DISEASE

作　　者：王贺波[1] 王天俊[1] 郭宗成[1] 张和振[1] 靳玮[1] 刘昌林[1] 冯亚青[1] 李玲[1] 赵大卫[1] 王建华[1] 吕佩源[1] 

机构地区：[1]河北省人民医院神经内科,石家庄050051

出　　处：《脑与神经疾病杂志》2008年第4期431-433,共3页Journal of Brain and Nervous Diseases

基　　金：河北省自然科学基金资助项目(301415)

摘　　要：目的:对皮质下缺血性脑血管病(SIVD)的临床特征、认知和MRI白质改变进行分析,初步探讨SIVD患者认知损害与MRI白质改变的关系。方法:经过访谈和详细查体,记录患者症状和体征,进行神经心理学评估并行头MRI扫描。依据Erkinjuntti提出MRI诊断标准确定SIVD患者29例。结果:认知正常者、血管性CIND患者和VaD患者的MMSE得分分别为(27.5±1.84)、(23.7±2.06)和(18±1.58)。随着认知功能损害程度的加重,其白质改变的评分增加,具有统计学显著差异。结论:SIVD患者的认知功能损害与其白质改变程度有关。Objective：To investigte the relationship of white matter changes and cognitive impairment in patients with subcortical ischemic vascular disease（SIVD）.Methods：The symptomes and signs were recorded by interview and examination,mutilple neuropsychological,magnetic resonance imaging rating scales were administrasted on 29 patients with SIVD according to the criteria of Erkinjuntti.Results：The score of MMSE in nomal cognition health,vascular cognitive impairment no dementia and vascular dementia patients were（27.5±1.84）,（23.7±2.06） and（18±1.58）,respectively.With the development of cognitive impairment,the white matter changes became greater.Conclusion：Cognitive impairment in patients with SIVD is associated with the progression of white matter changes.

关 键 词：皮质下缺血性脑血管病 白质改变 认知损害 血管性认知损害 

分 类 号：R743.32[医药卫生—神经病学与精神病学]