胃癌术后早期局部灌注化疗预防局部复发与肝转移的临床研究  

Clinical Study of Early Regional Infusion Chemotherapy for Prevention of Local Recurrence and Hepatic Metastasis after Radical Resection of Gastric Carcinoma

作　　者：刘战丛[1] 王丽萍[1] 王韶华[1] 

机构地区：[1]漯河医学高等专科学校第二附属医院(漯河市第五人民医院)普外科,河南漯河462300

出　　处：《中国现代医生》2008年第22期149-150,共2页China Modern Doctor

摘　　要：目的探讨胃癌术后早期局部灌注化疗预防局部复发与肝转移的价值。方法将1999年1月～2005年10月间收治的260例胃癌患者随机分为两组,治疗组130例行早期局部灌注化疗,对照组130例术后行全身静脉化疗,对两组的疗效进行分析。结果随访3～6年,对照组1年、3年、5年生存率为83.0%,49.2%和20.8%,而治疗组1年、3年、5年生存率为97.7%,83.0%和50.8%,两组间3年和5年生存率比较有显著差异。对照组局部复发率和肝转移率分别为24.6%和21.5%,治疗组则分别为8.5%和6.9%,两组比较差异有高度显著差异。结论术后早期局部灌注化疗可以提高胃癌患者的3年和5年生存率,预防局部复发和肝转移。Objective To evaluate the value of early regional infusion chemotherapy for prevention of local recurrence and hepatic metastasis after radical resection of gastric carcinoma. Methods 260 patients with gastric carcinoma undergoing radical resection were preoperatively randomly divided into two groups： Early regional infusion chemotherapy （treatment group,130 cases） and traditoinal peripheral venous chemotherapy （control group, 130 cases）. Results The 1- ,3-, and 5-year survival rate was 97.7%, 83.0% and 50.8% in the treatment group,and 83.0%, 49.2%and 20.8% in the control group. The local recurrence and hepatic metastasis rate was 8.5% and 6.9% in the treatment group, was 24.6% and 21.5% in the control group. Conclusion Earlyregional infusion chemotherapy is effective for prevention of local recurrence and hepatic metastasis.

关 键 词：胃癌 早期化疗 局部灌注 复发 肝转移 

分 类 号：R735.2[医药卫生—肿瘤]